Sviluppo e patologia cerebrale
Componenti
- Vercelli Alessandro (Responsabile scientifico)
- Boido Marina Maria (Componente)
- Tamagno Elena (Ricercatore)
- (Componente)
- Repetto Ivan Enrico (Componente)
- (Componente)
- Guglielmotto Michela (Altro personale)
- Manassero Giusi (Altro personale)
- Ghibaudi Matilde (Altro personale)
Contatti
Attività
Studiamo lo sviluppo del sistema nervoso centrale dall'embrione all’anziano, e alcuni meccanismi neurobiologici e percorsi molecolari comuni che guidano lo sviluppo normale ma che possono portare alla neurodegenerazione. In particolare, stiamo studiando corteccia cerebrale, retina e midollo spinale, e l'organizzazione delle vie visive, motorie e somatosensitive.
Siamo interessati alle vie molecolari che portano alla genesi e alla morte delle cellule neuronali, sia durante lo sviluppo, sia in modelli sperimentali di ischemia cerebrale transitoria o permanente (infarto cerebrale), di glaucoma acuto e cronico, nell'epilessia, nelle malattie del motoneurone e nel morbo di Alzheimer. Infine, valutiamo il ruolo immunomodulatorio, neuroprotettivo e stimolante la crescita assonale delle cellule staminali.
Il nostro gruppo di ricerca collabora con aziende biotecnologiche allo scopo di sviluppare strategie innovative per curare le malattie del sistema nervoso.
| Settore ERC del gruppo: |
|---|
| LS3_12 - Stem cell biology |
| LS3_2 - Cell biology and molecular transport mechanisms |
| LS3_3 - Cell cycle and division |
| LS3_4 - Apoptosis |
| LS3_5 - Cell differentiation, physiology and dynamics |
| LS3_6 - Organelle biology |
| LS3_7 - Cell signalling and cellular interactions |
| LS3_8 - Signal transduction |
| LS3_9 - Development, developmental genetics, pattern formation and embryology in animals |
| LS5_1 - Neuroanatomy and neurophysiology |
| LS5_10 - Neuroimaging and computational neuroscience |
| LS5_11 - Neurological disorders (e.g. Alzheimer's disease, Huntington's disease, Parkinson's disease) |
| LS5_12 - Psychiatric disorders (e.g. schizophrenia, autism, Tourette’s syndrome, obsessive compulsive disorder, depression, bipolar disorder, attention deficit hyperactivity disorder |
| LS5_2 - Molecular and cellular neuroscience |
| LS5_3 - Neurochemistry and neuropharmacology |
| LS5_4 - Sensory systems (e.g. visual system, auditory system) |
| LS5_5 - Mechanisms of pain |
| LS5_6 - Developmental neurobiology |
| LS7_6 - Gene therapy, cell therapy, regenerative medicine |
Prodotti della ricerca
Perino A, Beretta M, Kilic A, Ghigo A, Carnevale D, Repetto IE, Braccini L, Longo D, Liebig-Gonglach M, Zaglia T, Iacobucci R, Mongillo M, Wetzker R, Bauer M, Aime S, Vercelli A, Lembo G, Pfeifer A, Hirsch E. (2014) Combined inhibition of PI3Kbeta and PI3Kgamma reduces fat mass by enhancing alpha-MSH-dependent sympathetic drive. Science signaling 7(352) ra110 [DOI PMID]
Guglielmotto M, Monteleone D, Piras A, Valsecchi V, Tropiano M, Ariano S, Fornaro M, Vercelli A, Puyal J, Arancio O, Tabaton M, Tamagno E. (2014) Abeta1-42 monomers or oligomers have different effects on autophagy and apoptosis. Autophagy 10(10) 1827-43 [DOI PMID]
Queiroga CS, Vercelli A, Vieira HL. (2015) Carbon monoxide and the CNS: challenges and achievements. British journal of pharmacology 172(6) 1533-45 [DOI PMID]
Tomassy GS, Berger DR, Chen HH, Kasthuri N, Hayworth KJ, Vercelli A, Seung HS, Lichtman JW, Arlotta P. (2014) Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex. Science (New York, N.Y.) 344(6181) 319-24 [DOI PMID]
d'Errico P, Boido M, Piras A, Valsecchi V, De Amicis E, Locatelli D, Capra S, Vagni F, Vercelli A, Battaglia G. (2013) Selective vulnerability of spinal and cortical motor neuron subpopulations in delta7 SMA mice. PloS one 8(12) e82654 [DOI PMID]
Innocenti GM, Vercelli A, Caminiti R. (2014) The diameter of cortical axons depends both on the area of origin and target. Cerebral cortex (New York, N.Y. : 1991) 24(8) 2178-88 [DOI PMID]
Mazzini L, Vercelli A, Ferrero I, Boido M, Cantello R, Fagioli F. (2012) Transplantation of mesenchymal stem cells in ALS. Progress in brain research 201 333-59 [DOI PMID]
Tamagno E, Guglielmotto M, Monteleone D, Vercelli A, Tabaton M. (2012) Transcriptional and post-transcriptional regulation of beta-secretase. IUBMB life 64(12) 943-50 [DOI PMID]
Verderio C, Muzio L, Turola E, Bergami A, Novellino L, Ruffini F, Riganti L, Corradini I, Francolini M, Garzetti L, Maiorino C, Servida F, Vercelli A, Rocca M, Dalla Libera D, Martinelli V, Comi G, Martino G, Matteoli M, Furlan R. (2012) Myeloid microvesicles are a marker and therapeutic target for neuroinflammation. Annals of neurology 72(4) 610-24 [DOI PMID]
Boido M, Garbossa D, Fontanella M, Ducati A, Vercelli A. (2014) Mesenchymal stem cell transplantation reduces glial cyst and improves functional outcome after spinal cord compression. World neurosurgery 81(1) 183-90 [DOI PMID]
Queiroga CS, Tomasi S, Wideroe M, Alves PM, Vercelli A, Vieira HL. (2012) Preconditioning triggered by carbon monoxide (CO) provides neuronal protection following perinatal hypoxia-ischemia. PloS one 7(8) e42632 [DOI PMID]
Guglielmotto M, Monteleone D, Boido M, Piras A, Giliberto L, Borghi R, Vercelli A, Fornaro M, Tabaton M, Tamagno E. (2012) Abeta1-42-mediated down-regulation of Uch-L1 is dependent on NF-kappaB activation and impaired BACE1 lysosomal degradation. Aging cell 11(5) 834-44 [DOI PMID]
Zhao Y, Spigolon G, Bonny C, Culman J, Vercelli A, Herdegen T. (2012) The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria. Molecular and cellular neurosciences 49(3) 300-10 [DOI PMID]
Morello N, Bianchi FT, Marmiroli P, Tonoli E, Rodriguez Menendez V, Silengo L, Cavaletti G, Vercelli A, Altruda F, Tolosano E. (2011) A role for hemopexin in oligodendrocyte differentiation and myelin formation. PloS one 6(5) e20173 [DOI PMID]
Boido M, Garbossa D, Vercelli A. (2011) Early graft of neural precursors in spinal cord compression reduces glial cyst and improves function. Journal of neurosurgery. Spine 15(1) 97-106 [DOI PMID]
Bartolini A, Vigliani MC, Magrassi L, Vercelli A, Rossi F. (2011) G-CSF administration to adult mice stimulates the proliferation of microglia but does not modify the outcome of ischemic injury. Neurobiology of disease 41(3) 640-9 [DOI PMID]
Grande V, Manassero G, Vercelli A. (2014) Neuroprotective and anti-inflammatory roles of the phosphatase and tensin homolog deleted on chromosome Ten (PTEN) Inhibition in a Mouse Model of Temporal Lobe Epilepsy. PloS one 9(12) e114554 [DOI PMID]
Boido M, Piras A, Valsecchi V, Spigolon G, Mareschi K, Ferrero I, Vizzini A, Temi S, Mazzini L, Fagioli F, Vercelli A. (2014) Human mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in a mouse model of amyotrophic lateral sclerosis. Cytotherapy 16(8) 1059-72 [DOI PMID]
Cauda F, Geminiani GC, Vercelli A. (2014) Evolutionary appearance of von Economo's neurons in the mammalian cerebral cortex. Frontiers in human neuroscience 8 104 [DOI PMID]
Vercelli A, Boido M, Jhaveri S. (2012) NADPH diaphorase expression in superior colliculus of developing, aging and visually deafferented rats. Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia 117(3) 142-66 [PMID]
Gunetti M, Tomasi S, Giammo A, Boido M, Rustichelli D, Mareschi K, Errichiello E, Parola M, Ferrero I, Fagioli F, Vercelli A, Carone R. (2012) Myogenic potential of whole bone marrow mesenchymal stem cells in vitro and in vivo for usage in urinary incontinence. PloS one 7(9) e45538 [DOI PMID]
Cauda F, Vercelli A. (2013) How many clusters in the insular cortex? Cerebral cortex (New York, N.Y. : 1991) 23(11) 2779-80 [DOI PMID]
Manassero G, Repetto IE, Cobianchi S, Valsecchi V, Bonny C, Rossi F, Vercelli A. (2012) Role of JNK isoforms in the development of neuropathic pain following sciatic nerve transection in the mouse. Molecular pain 8 39 [DOI PMID]
Garbossa D, Boido M, Fontanella M, Fronda C, Ducati A, Vercelli A. (2012) Recent therapeutic strategies for spinal cord injury treatment: possible role of stem cells. Neurosurgical review 35(3) 293-311; discussion 311 [DOI PMID]
Cauda F, Costa T, Torta DM, Sacco K, D'Agata F, Duca S, Geminiani G, Fox PT, Vercelli A. (2012) Meta-analytic clustering of the insular cortex: characterizing the meta-analytic connectivity of the insula when involved in active tasks. NeuroImage 62(1) 343-55 [DOI PMID]
Cauda F, Torta DM, Sacco K, D'Agata F, Geda E, Duca S, Geminiani G, Vercelli A. (2013) Functional anatomy of cortical areas characterized by Von Economo neurons. Brain structure & function 218(1) 1-20 [DOI PMID]
Piras A, Gianetto D, Conte D, Bosone A, Vercelli A. (2011) Activation of autophagy in a rat model of retinal ischemia following high intraocular pressure. PloS one 6(7) e22514 [DOI PMID]
Tomasi S, Sarmientos P, Giorda G, Gurewich V, Vercelli A. (2011) Mutant prourokinase with adjunctive C1-inhibitor is an effective and safer alternative to tPA in rat stroke. PloS one 6(7) e21999 [DOI PMID]
Buschini E, Piras A, Nuzzi R, Vercelli A. (2011) Age related macular degeneration and drusen: neuroinflammation in the retina. Progress in neurobiology 95(1) 14-25 [DOI PMID]
Vieira HL, Alves PM, Vercelli A. (2011) Modulation of neuronal stem cell differentiation by hypoxia and reactive oxygen species. Progress in neurobiology 93(3) 444-55 [DOI PMID]
Cauda F, D'Agata F, Sacco K, Duca S, Geminiani G, Vercelli A. (2011) Functional connectivity of the insula in the resting brain. NeuroImage 55(1) 8-23 [DOI PMID]