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Organizzazione delle sinapsi e sviluppo

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Attività

Siamo interessati ai meccanismi che regolano lo sviluppo e la plasticità delle sinapsi nel sistema nervoso centrale. Il gruppo studia in particolare le sinapsi GABAergiche, che sono le principali sinapsi inibitorie a livello encefalico. Utilizzando animali geneticamente modificati e tecniche di “imaging” ad alta risoluzione, analizziamo il ruolo dei recettori del GABA, di molecole di adesione e di proteine strutturali nella sinaptogenesi. In parallelo, studiamo difetti sinaptici in modelli murini di patologie neurologiche, tra cui la sclerosi multipla (in collaborazione con Annalisa Buffo), la sindrome di Rett (in collaborazione con Maurizio Giustetto) e le distrofie muscolari.

Settore ERC del gruppo:
LS5_1 - Neuroanatomy and neurophysiology
LS5_2 - Molecular and cellular neuroscience
LS5_3 - Neurochemistry and neuropharmacology

Prodotti della ricerca

Sassoe-Pognetto M. (2011) Molecular and functional heterogeneity of neural circuits: an example from the olfactory bulb. Brain research reviews 66(1-2) 35-42 [DOI  PMID]

Wolf M, Zimmermann AM, Gorlich A, Gurniak CB, Sassoe-Pognetto M, Friauf E, Witke W, Rust MB. (2014) ADF/Cofilin Controls Synaptic Actin Dynamics and Regulates Synaptic Vesicle Mobilization and Exocytosis. Cerebral cortex (New York, N.Y. : 1991) [DOI  PMID]

Zimmermann AM, Jene T, Wolf M, Gorlich A, Gurniak CB, Sassoe-Pognetto M, Witke W, Friauf E, Rust MB. (2014) Attention-Deficit/Hyperactivity Disorder-like Phenotype in a Mouse Model with Impaired Actin Dynamics. Biological psychiatry [DOI  PMID]

Arroyo AI, Camoletto PG, Morando L, Sassoe-Pognetto M, Giustetto M, Van Veldhoven PP, Schuchman EH, Ledesma MD. (2014) Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model. EMBO molecular medicine 6(3) 398-413 [DOI  PMID]

Pregno G, Frola E, Graziano S, Patrizi A, Bussolino F, Arese M, Sassoe-Pognetto M. (2013) Differential regulation of neurexin at glutamatergic and GABAergic synapses. Frontiers in cellular neuroscience 7 35 [DOI  PMID]

Petrash HA, Philbrook A, Haburcak M, Barbagallo B, Francis MM. (2013) ACR-12 ionotropic acetylcholine receptor complexes regulate inhibitory motor neuron activity in Caenorhabditis elegans. The Journal of neuroscience : the official journal of the Society for Neuroscience 33(13) 5524-32 [DOI  PMID]

Frola E, Patrizi A, Goetz T, Medrihan L, Petrini EM, Barberis A, Wulff P, Wisden W, Sassoe-Pognetto M. (2013) Synaptic competition sculpts the development of GABAergic axo-dendritic but not perisomatic synapses. PloS one 8(2) e56311 [DOI  PMID]

Ciccarelli A, Calza A, Santoru F, Grasso F, Concas A, Sassoe-Pognetto M, Giustetto M. (2013) Morphine withdrawal produces ERK-dependent and ERK-independent epigenetic marks in neurons of the nucleus accumbens and lateral septum. Neuropharmacology 70 168-79 [DOI  PMID]

Ciccarelli A, Calza A, Panzanelli P, Concas A, Giustetto M, Sassoe-Pognetto M. (2012) Organization of GABAergic synaptic circuits in the rat ventral tegmental area. PloS one 7(10) e46250 [DOI  PMID]

Pallotto M, Nissant A, Fritschy JM, Rudolph U, Sassoe-Pognetto M, Panzanelli P, Lledo PM. (2012) Early formation of GABAergic synapses governs the development of adult-born neurons in the olfactory bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience 32(26) 9103-15 [DOI  PMID]

Sodero AO, Vriens J, Ghosh D, Stegner D, Brachet A, Pallotto M, Sassoe-Pognetto M, Brouwers JF, Helms JB, Nieswandt B, Voets T, Dotti CG. (2012) Cholesterol loss during glutamate-mediated excitotoxicity. The EMBO journal 31(7) 1764-73 [DOI  PMID]

Katagiri H, Pallotto M, Nissant A, Murray K, Sassoe-Pognetto M, Lledo PM. (2011) Dynamic development of the first synapse impinging on adult-born neurons in the olfactory bulb circuit. Neural systems & circuits 1(1) 6 [DOI  PMID]

Gorlich A, Zimmermann AM, Schober D, Bottcher RT, Sassoe-Pognetto M, Friauf E, Witke W, Rust MB. (2012) Preserved morphology and physiology of excitatory synapses in profilin1-deficient mice. PloS one 7(1) e30068 [DOI  PMID]

Gorlich A, Wolf M, Zimmermann AM, Gurniak CB, Al Banchaabouchi M, Sassoe-Pognetto M, Witke W, Friauf E, Rust MB. (2011) N-cofilin can compensate for the loss of ADF in excitatory synapses. PloS one 6(10) e26789 [DOI  PMID]

Sassoe-Pognetto M, Frola E, Pregno G, Briatore F, Patrizi A. (2011) Understanding the molecular diversity of GABAergic synapses. Frontiers in cellular neuroscience 5 4 [DOI  PMID]

Patrizi A, Viltono L, Frola E, Harvey K, Harvey RJ, Sassoe-Pognetto M. (2012) Selective localization of collybistin at a subset of inhibitory synapses in brain circuits. The Journal of comparative neurology 520(1) 130-41 [DOI  PMID]

Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt KF, Sassoe-Pognetto M, Lowel S, Moser T, Taschenberger H, Brose N, Varoqueaux F. (2011) Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina. Proceedings of the National Academy of Sciences of the United States of America 108(7) 3053-8 [DOI  PMID]

Shepherd GM, Greer CA, Mazzarello P, Sassoe-Pognetto M. (2011) The first images of nerve cells: Golgi on the olfactory bulb 1875. Brain research reviews 66(1-2) 92-105 [DOI  PMID]

Briatore F, Patrizi A, Viltono L, Sassoe-Pognetto M, Wulff P. (2010) Quantitative organization of GABAergic synapses in the molecular layer of the mouse cerebellar cortex. PloS one 5(8) e12119 [DOI  PMID]

Saiepour L, Fuchs C, Patrizi A, Sassoe-Pognetto M, Harvey RJ, Harvey K. (2010) Complex role of collybistin and gephyrin in GABAA receptor clustering. The Journal of biological chemistry 285(38) 29623-31 [DOI  PMID]

Rust MB, Gurniak CB, Renner M, Vara H, Morando L, Gorlich A, Sassoe-Pognetto M, Banchaabouchi MA, Giustetto M, Triller A, Choquet D, Witke W. (2010) Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics. The EMBO journal 29(11) 1889-902 [DOI  PMID]

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