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Neuroscienze Cliniche

Componenti

Attività

Il gruppo di ricerca si occupa di cefalee primarie e secondarie, di sindromi atassiche e di malattie demielinizzanti (in particolare sclerosi multipla). L’approccio a tali patologie si articola tramite studi clinici, genetici, di neuroimaging e di immunopatologia. E’ in corso lo studio dei fattori di genere che possono modulare la storia clinica di malattia nelle cefalee e nelle sindromi demielinizzanti. Tramite network nazionali (Genova, Milano, Bari) ed internazionali (Toronto, Parigi, Londra) è in corso la genotipizzazione degli affetti per l’isolamento di nuovi fattori di rischio. Il gruppo è coinvolto in studi farmacologici di Fase III e Fase IV per valutare l’efficacia e la sicurezza di farmaci immunomodulatori (DMD) nella sclerosi multipla.

Settore ERC del gruppo:
LS2_6 - Molecular genetics, reverse genetics and RNAi
LS5_5 - Mechanisms of pain
LS6_6 - Immunogenetics

Prodotti della ricerca

Govone F, Vacca A, Rubino E, Gai A, Boschi S, Gentile S, Orsi L, Pinessi L, Rainero I. (2014) Lack of association between APOE gene polymorphisms and amyotrophic lateral sclerosis: a comprehensive meta-analysis. Amyotrophic lateral sclerosis & frontotemporal degeneration 15(7-8) 551-6 [DOI  PMID]

Rainero I, Rubino E, Paemeleire K, Gai A, Vacca A, De Martino P, Gentile S, Sarchielli P, Pinessi L. (2013) Genes and primary headaches: discovering new potential therapeutic targets. The journal of headache and pain 14 61 [DOI  PMID]

Rubino E, Giorgio E, Gallone S, Pinessi L, Orsi L, Gentile S, Duca S, Brusco A. (2014) Novel mutation of SLC20A2 in an Italian patient presenting with migraine. Journal of neurology 261(10) 2019-21 [DOI  PMID]

Baudino B, D'agata F, Caroppo P, Castellano G, Cauda S, Manfredi M, Geda E, Castelli L, Mortara P, Orsi L, Cauda F, Sacco K, Ardito RB, Pinessi L, Geminiani G, Torta R, Bisi G. (2012) The chemotherapy long-term effect on cognitive functions and brain metabolism in lymphoma patients. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology 56(6) 559-68 [PMID]

Rubino E, Vacca A, Govone F, De Martino P, Pinessi L, Rainero I. (2013) Apolipoprotein E polymorphisms in frontotemporal lobar degeneration: a meta-analysis. Alzheimer's & dementia : the journal of the Alzheimer's Association 9(6) 706-13 [DOI  PMID]

Rubino E, Fenoglio P, Gallone S, Govone F, Vacca A, De Martino P, Giobbe ML, Boschi S, Pinessi L, Gentile S, Rainero I. (2013) Genetic variants in the NOTCH4 gene influence the clinical features of migraine. The journal of headache and pain 14(1) 28 [DOI  PMID]

Rubino E, Rainero I, Chio A, Rogaeva E, Galimberti D, Fenoglio P, Grinberg Y, Isaia G, Calvo A, Gentile S, Bruni AC, St George-Hyslop PH, Scarpini E, Gallone S, Pinessi L. (2012) SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Neurology 79(15) 1556-62 [DOI  PMID]

Giorgio E, Vaula G, Bosco G, Giacone S, Mancini C, Calcia A, Cavalieri S, Di Gregorio E, Rigault De Longrais R, Leombruni S, Pinessi L, Cerrato P, Brusco A, Brussino A. (2015) Two families with novel missense mutations in COL4A1: When diagnosis can be missed. Journal of the neurological sciences [DOI  PMID]

Zhang M, Xi Z, Zinman L, Bruni AC, Maletta RG, Curcio SA, Rainero I, Rubino E, Pinessi L, Nacmias B, Sorbi S, Galimberti D, Lang AE, Fox S, Surace EI, Ghani M, Guo J, Sato C, Moreno D, Liang Y, Keith J, Traynor BJ, St George-Hyslop P, Rogaeva E. (2015) Mutation analysis of CHCHD10 in different neurodegenerative diseases. Brain : a journal of neurology [DOI  PMID]

Peila E, Mortara P, Cicerale A, Pinessi L. (2015) Paroxysmal non-kinesigenic dyskinesia, post-streptococcal syndromes and psychogenic movement disorders: a diagnostic challenge. BMJ case reports 2015 [DOI  PMID]

Xi Z, Zhang M, Bruni AC, Maletta RG, Colao R, Fratta P, Polke JM, Sweeney MG, Mudanohwo E, Nacmias B, Sorbi S, Tartaglia MC, Rainero I, Rubino E, Pinessi L, Galimberti D, Surace EI, McGoldrick P, McKeever P, Moreno D, Sato C, Liang Y, Keith J, Zinman L, Robertson J, Rogaeva E. (2015) The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients. Acta neuropathologica 129(5) 715-27 [DOI  PMID]

Condello C, Piano V, Dadam D, Pinessi L, Lanteri-Minet M. (2015) Pain beliefs and perceptions inventory: a cross-sectional study in chronic and episodic migraine. Headache 55(1) 136-48 [DOI  PMID]

Masera S, Cavalla P, Prosperini L, Mattioda A, Mancinelli C, Superti G, Chiavazza C, Vercellino M, Pinessi L, Pozzilli C. (2014) Parity is associated with a longer time to reach irreversible disability milestones in women with multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England) [DOI  PMID]

Soffietti R, Bertero L, Pinessi L, Ruda R. (2014) Pharmacologic therapies for malignant glioma: a guide for clinicians. CNS drugs 28(12) 1127-37 [DOI  PMID]

Rainero I, Rubino E, Gallone S, Zavarise P, Carli D, Boschi S, Fenoglio P, Savi L, Gentile S, Benna P, Pinessi L, Dalla Volta G. (2014) KCNK18 (TRESK) genetic variants in Italian patients with migraine. Headache 54(9) 1515-22 [DOI  PMID]

Pellerino A, Cassoni P, Boldorini R, Pinessi L, Ruda R. (2015) Response to combined radiotherapy and chemotherapy of a leptomeningeal spread from choroid plexus carcinoma: case report. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 36(4) 639-41 [DOI  PMID]

Gallone S, Boschi S, Rubino E, De Martino P, Scarpini E, Galimberti D, Fenoglio C, Acutis PL, Maniaci MG, Pinessi L, Rainero I. (2014) Is HCRTR2 a genetic risk factor for Alzheimer's disease? Dementia and geriatric cognitive disorders 38(3-4) 245-53 [DOI  PMID]

Ultimo aggiornamento: 18/05/2015 17:34
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