Prof. Adriano CHIO'

Professore Ordinario

Contatti

Presso

Curriculum vitae

Pubblicazioni selezionate

Elenco pubblicazioni dal 2010

 

2018

 

Marrali G, Casale F, Salamone P, Fuda G, Ilardi A, Manera U, Calvo A, Zibetti M, Lopiano L, Chiò A. NADPH oxidases 2 activation in patients with Parkinson's disease. Parkinsonism Relat Disord. 2018 Jan 5. pii: S1353-8020(18)30003-8. doi:  10.1016/j.parkreldis.2018.01.003. [Epub ahead of print] PubMed PMID: 29331562.

 

Vasta R, Calvo A, Moglia C, Cammarosano S, Manera U, Canosa A, D'Ovidio F, Mazzini L, Chiò A. Spatial epidemiology of Amyotrophic Lateral Sclerosis in Piedmont and Aosta Valley, Italy: a population-based cluster analysis. Eur J Neurol 2018 Jan 27. doi: 10.1111/ene.13586.

 

2017

 

Calvo A, Moglia C, Lunetta C, Marinou K, Ticozzi N, Ferrante GD, Scialo C, Sorarù G, Trojsi F, Conte A, Falzone YM, Tortelli R, Russo M, Chiò A, Sansone VA, Mora G, Silani V, Volanti P, Caponnetto C, Querin G, Monsurrò MR, Sabatelli M, Riva N, Logroscino G, Messina S, Fini N, Mandrioli J. Factors predicting survival in ALS: a multicenter Italian study. J Neurol. 2017 Jan;264(1):54-63. doi: 10.1007/s00415-016-8313-y.

 

Chiò A, Mora G, Lauria G. Pain in amyotrophic lateral sclerosis. Lancet Neurol. 2017 Feb;16(2):144-157. doi: 10.1016/S1474-4422(16)30358-1

 

Arthur KC, Doyle C, Chiò A, Traynor BJ. Use of Genetic Testing in Amyotrophic Lateral Sclerosis by Neurologists. JAMA Neurol. 2017 Jan 1;74(1):125-126. doi: 10.1001/jamaneurol.2016.4540.

 

Monti C, Colugnat I, Lopiano L, Chiò A, Alberio T. Network Analysis Identifies Disease-Specific Pathways for Parkinson's Disease. Mol Neurobiol. 2016 Dec 21. doi: 10.1007/s12035-016-0326-0. [Epub ahead of print] PubMed PMID: 28004338.

 

Tesauro M, Consonni M, Filippini T, Mazzini L, Pisano F, Chiò A, Esposito A, Vinceti M. Incidence of amyotrophic lateral sclerosis in the province of Novara, Italy, and possible role of environmental pollution. Amyotroph Lateral Scler Frontotemporal Degener. 2017 Feb 2:1-7. doi: 10.1080/21678421.2017.1281961. [Epub ahead of print] PubMed PMID: 28152620.

 

Meininger V, Genge A, van den Berg LH, Robberecht W, Ludolph A, Chiò A, Kim SH, Leigh PN, Kiernan MC, Shefner JM, Desnuelle C, Morrison KE, Petri S, Boswell D, Temple J, Mohindra R, Davies M, Bullman J, Rees P, Lavrov A; NOG112264 Study Group.. Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Neurol 2017 Mar;16(3):208-216. doi: 10.1016/S1474-4422(16)30399-4.

 

Stopford MJ, Higginbottom A, Hautbergue GM, Cooper-Knock J, Mulcahy PJ, De Vos KJ, Renton AE, Pliner H, Calvo A, Chiò A, Traynor BJ, Azzouz M, Heath PR, Consortium I, Consortium N, Kirby J, Shaw PJ. C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten. Hum Mol Genet. 2017 Mar 15;26(6):1133-1145.

 

D'Ovidio F, d'Errico A, Calvo A, Costa G, Chiò A. Occupations and amyotrophic lateral sclerosis: are jobs exposed to the general public at higher risk? Eur J Public Health. 2017 Feb 14. doi: 10.1093/eurpub/ckx006. [Epub ahead of print] PubMed PMID: 28201634.

 

Hardiman O, Chalabi AA, Brayne C, Beghi E, van den Berg LH, Chiò A, Martin S, Logroscino G, Rooney J. The changing picture of amyotrophic lateral sclerosis: lessons from European registers. J Neurol Neurosurg Psychiatry. 2017 Mar 11. pii: jnnp-2016-314495. doi: 10.1136/jnnp-2016-314495.

 

Perga S, Martire S, Montarolo F, Navone ND, Calvo A, Fuda G, Marchet A, Leotta D, Chiò A, Bertolotto A(3). A20 in Multiple Sclerosis and Parkinson's Disease: Clue to a Common Dysregulation of Anti-Inflammatory Pathways? Neurotox Res. 2017 Mar 23. doi: 10.1007/s12640-017-9724-y.

 

Filareti M, Luotti S, Pasetto L, Pignataro M, Paolella K, Messina P, Pupillo E, Filosto M, Lunetta C, Mandrioli J, Fuda G, Calvo A, Chiò A, Corbo M, Bendotti C, Beghi E, Bonetto V. Decreased levels of foldase and chaperone proteins are associated with an early-onset amyotrophic lateral sclerosis.Front Mol Neurosci 2017. doi: 10.3389/fnmol.2017.00099

 

McLaughlin RL, Schijven D, van Rheenen W, van Eijk KR, O'Brien M, Kahn RS, Ophoff RA, Goris A, Bradley DG, Al-Chalabi A, van den Berg LH, Luykx JJ, Hardiman O, Veldink JH; Project MinE GWAS Consortium (including Chiò A); Schizophrenia Working Group of the Psychiatric Genomics Consortium.. Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nat Commun. 2017 Mar 21;8:14774. doi: 10.1038/ncomms14774

 

Lunetta C, Lizio A, Maestri E, Sansone VA, Mora G, Miller RG, Appel SH, Chiò A. Serum C-Reactive Protein as a Prognostic Biomarker in Amyotrophic Lateral Sclerosis. JAMA Neurol. 2017 Apr 3. doi: 10.1001/jamaneurol.2016.6179. [Epub ahead of print]

 

Murphy NA, Arthur KC, Tienari PJ, Houlden H, Chiò A, Traynor BJ. Age-related penetrance of the C9orf72 repeat expansion. Sci Rep. 2017 May 18;7(1):2116. doi: 10.1038/s41598-017-02364-1.

 

Cavallieri F, Mandrioli J, Rosafio F, Contardi S, Fasano A, Menozzi E, Caponnetto C, Chiò A, Valzania F. C9ORF72 and parkinsonism: Weak link, innocent bystander, or central player in neurodegeneration? J Neurol Sci. 2017 Jul 15;378:49-51.

 

van Es MA, Hardiman O, Chiò A, Al-Chalabi A, Pasterkamp RJ, Veldink JH, van den Berg LH. Amyotrophic lateral sclerosis. Lancet. 2017 May 25. pii: S0140-6736(17)31287-4.

 

Calvo A, Moglia C, Canosa A, Cammarosano S, Ilardi A, Bertuzzo D, Traynor BJ, Brunetti M, Barberis M, Mora G, Casale F, Chiò A. Common polymorphisms of chemokine (C-X3-C motif) receptor 1 gene modify amyotrophic lateral sclerosis outcome: A population-based study. Muscle Nerve. 2017 Mar 25. doi: 10.1002/mus.25653.

 

D'Ovidio F, Rooney JPK, Visser AE, Vermeulen RCH, Veldink JH, Van Den Berg LH, Hardiman O, Logroscino G, Chiò A, Beghi E; Euro-MOTOR Group. Critical issues in ALS case-control studies: the case of the Euro-MOTOR study. Amyotroph Lateral Scler Frontotemporal Degener. 2017 Feb 10:1-8. doi: 10.1080/21678421.2017.1285939.

 

Moglia C, Calvo A, Canosa A, Bertuzzo D, Cugnasco P, Solero L, Grassano M, Bersano E, Cammarosano S, Manera U; Parals, Pisano F, Mazzini L, Dalla Vecchia LA, Mora G, Chiò A. Influence of arterial hypertension, type 2 diabetes and cardiovascular risk factors on ALS outcome: a population-based study. Amyotroph Lateral Scler Frontotemporal Degener. 2017 Jun 15:1-7. doi: 10.1080/21678421.2017.1336560.

 

Turner MR, Al-Chalabi A, Chio A, Hardiman O, Kiernan MC, Rohrer JD, Rowe J, Seeley W, Talbot K. Genetic screening in sporadic ALS and FTD. J Neurol Neurosurg Psychiatry. 2017 Jun 22. pii: jnnp-2017-315995. doi: 10.1136/jnnp-2017-315995.

 

Chiò A, Mora G, Moglia C, Manera U, Canosa A, Cammarosano S, Ilardi A, Bertuzzo D, Bersano E, Cugnasco P, Grassano M, Pisano F, Mazzini L, Calvo A; Piemonte and Valle d'Aosta Register for ALS (PARALS). Secular Trends of Amyotrophic Lateral Sclerosis: The Piemonte and Valle d'Aosta Register. JAMA Neurol. 2017; 74(9):1097-1104.

 

Ferraro PM, Agosta F, Riva N, Copetti M, Spinelli EG, Falzone Y, Sorarù G, Comi G, Chiò A, Filippi M. Multimodal structural MRI in the diagnosis of motor neuron diseases. Neuroimage Clin. 2017 Aug 2;16:240-247. doi: 10.1016/j.nicl.2017.08.002.

 

Sorce S, Stocker R, Seredenina T, Holmdahl R, Aguzzi A, Chio A, Depaulis A, Heitz F, Olofsson P, Olsson T, Duveau V, Sanoudou D, Skosgater S, Vlahou A, Wasquel D, Krause KH, Jaquet V. NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence? Free Radic Biol Med. 2017 Aug 12;112:387-396.

 

Bella ED, Tramacere I, Antonini G, Borghero G, Capasso M, Caponnetto C, Chiò A, Corbo M, Eleopra R, Filosto M, Giannini F, Granieri E, Bella V, Lunetta C, Mandrioli J, Mazzini L, Messina S, Monsurrò MR, Mora G, Riva N, Rizzi R, Siciliano G, Silani V, Simone I, Sorarù G, Volanti P, Lauria G. Protein misfolding, amyotrophic lateral sclerosis and guanabenz: protocol for a phase II RCT with futility design (ProMISe trial). BMJ Open. 2017 Aug 11;7(8):e015434.

 

Rooney JPK, Visser AE, D'Ovidio F, Vermeulen R, Beghi E, Chio A, Veldink JH, Logroscino G, van den Berg LH, Hardiman O; Euro-MOTOR Consortium. A case-control study of hormonal exposures as etiologic factors for ALS in women: Euro-MOTOR. Neurology 2017 Sep 19;89(12):1283-1290.

 

D'Ovidio F, d'Errico A, Carnà P, Calvo A, Costa G, Chiò A. The role of pre-morbid diabetes on developing Amyotrophic Lateral Sclerosis. Eur J Neurol. 2017 Sep 18. doi: 10.1111/ene.13465. [Epub ahead of print] PubMed PMID: 28921834.

 

Trojsi F, Siciliano M, Femiano C, Santangelo G, Lunetta C, Calvo A, Moglia C,  Marinou K, Ticozzi N, Drago Ferrante G, Scialò C, Sorarù G, Conte A, Falzone YM, Tortelli R, Russo M, Sansone VA, Chiò A, Mora G, Poletti B, Volanti P, Caponnetto C, Querin G, Sabatelli M, Riva N, Logroscino G, Messina S, Fasano A, Monsurrò MR, Tedeschi G, Mandrioli J. Comorbidity of dementia with amyotrophic lateral sclerosis (ALS): insights from a large multicenter Italian cohort. J Neurol. 2017 Sep 15. doi: 10.1007/s00415-017-8619-4. [Epub ahead of print] PubMed PMID: 28914354.

 

Hardiman O, Al-Chalabi A, Chio A, Corr EM, Logroscino G, Robberecht W, Shaw PJ, Simmons Z, van den Berg LH. Amyotrophic lateral sclerosis. Nat Rev Dis Primers. 2017 Oct 20;3:17085.

 

van Eijk RPA, Jones AR, Sproviero W, Shatunov A, Shaw PJ, Leigh PN, Young CA, Shaw CE, Mora G, Mandrioli J, Borghero G, Volanti P, Diekstra FP, van Rheenen W, Verstraete E, Eijkemans MJC, Veldink JH, Chiò A, Al-Chalabi A, van den Berg LH, van Es MA; For UKMND-LiCALS and LITALS Study Group. Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials. Neurology. 2017 Oct 31;89(18):1915-1922.

 

Al-Chalabi A, Andersen PM, Chandran S, Chiò A, Corcia P, Couratier P, Danielsson O, de Carvalho M, Desnuelle C, Grehl T, Grosskreutz J, Holmøy T, Ingre C, Karlsborg M, Kleveland G, Christoph Koch J, Koritnik B, Kuzma Kozakiewicz M, Laaksovirta H, Ludolph A, McDermott C, Meyer T, Mitre Ropero B, Mora Pardina J, Nygren I, Petri S, Povedano Panades M, Salachas F, Shaw P, Silani V, Staaf G, Svenstrup K, Talbot K, Tysnes OB, Van Damme P, van der Kooi A, Weber M, Weydt P,  Wolf J, Hardiman O, van den Berg LH. July 2017 ENCALS statement on edaravone. Amyotroph Lateral Scler Frontotemporal Degener. 2017 Oct 4:1-4.

 

Simone R, Balendra R, Moens TG, Preza E, Wilson KM, Heslegrave A, Woodling NS, Niccoli T, Gilbert-Jaramillo J, Abdelkarim S, Clayton EL, Clarke M, Konrad MT, Nicoll AJ, Mitchell JS, Calvo A, Chio A, Houlden H, Polke JM, Ismail MA, Stephens CE, Vo T, Farahat AA, Wilson WD, Boykin DW, Zetterberg H, Partridge L, Wray S, Parkinson G, Neidle S, Patani R, Fratta P, Isaacs AM. G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo. EMBO Mol Med. 2018 Jan;10(1):22-31.

 

Chia R, Chiò A, Traynor BJ. Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications. Lancet Neurol. 2018 Jan;17(1):94-102.

 

Cooper-Knock J, Robins H, Niedermoser I, Wyles M, Heath PR, Higginbottom A, Walsh T, Kazoka M; Project MinE ALS Sequencing Consortium (including Chio A), Ince PG, Hautbergue GM, McDermott CJ, Kirby J, Shaw PJ. Targeted Genetic Screen in Amyotrophic Lateral Sclerosis Reveals Novel Genetic Variants with Synergistic Effect on Clinical Phenotype. Front Mol Neurosci. 2017 Nov 9;10:370.

 

Van Der Spek RA, Van Rheenen W, Pulit SL, Kenna KP, Ticozzi N, Kooyman M, McLaughlin RL, Moisse M, Van Eijk KR, Van Vugt JJFA, Andersen P, Nazli Basak A, Blair I, De Carvalho M, Chio A, Corcia P, Couratier P, Drory VE, Glass JD, Hardiman O, Mora JS, Morrison KE, Mitne-Neto M, Robberecht W, Shaw PJ, Panadés MP, Van Damme P, Silani V, Gotkine M, Weber M, Van Es MA, Landers JE, Al-Chalabi A, Van Den Berg LH, Veldink JH; PROJECT MINE ALS SEQUENCING CONSORTIUM. Reconsidering the causality of TIA1 mutations in ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2017 Dec 13:1-3.

 

Pupillo E, Bianchi E, Chiò A, Casale F, Zecca C, Tortelli R, Beghi E; For Slalom; Parals; and for Slap Groups. Amyotrophic lateral sclerosis and food intake. Amyotroph Lateral Scler Frontotemporal Degener. 2017 Dec 21:1-8.

 

Pupillo E, Poloni M, Bianchi E, Giussani G, Logroscino G, Zoccolella S, Chiò A, Calvo A, Corbo M, Lunetta C, Marin B, Mitchell D, Hardiman O, Rooney J, Stevic Z, Bandettini di Poggio M, Filosto M, Cotelli MS, Perini M, Riva N, Tremolizzo L, Vitelli E, Damiani D, Beghi E; EURALS Consortium. Trauma and amyotrophic lateral sclerosis: a european population-based case-control study from the EURALS consortium. Amyotroph Lateral Scler Frontotemporal Degener. 2017 Oct 24:1-8.

 

2016

 

Floris G, Borghero G, Di Stefano F, Melis R, Puddu R, Fadda L, Murru MR, Corongiu D, Cuccu S, Tranquilli S, Cannas A, Marrosu MG, Chiò A, Marrosu F. Phenotypic variability related to C9orf72 mutation in a large Sardinian kindred. Amyotroph Lateral Scler Frontotemporal Degener. 2016 Apr-May;17(3-4):245-8. doi: 10.3109/21678421.2015.1111904.

 

Canosa A, Pagani M, Cistaro A, Montuschi A, Iazzolino B, Fania P, Cammarosano S, Ilardi A, Moglia C, Calvo A, Chiò A. 18F-FDG-PET correlates of cognitive impairment in ALS. Neurology 2016; 86:44-49

 

Chiò A, Lauria G. Degenerative neuromuscular diseases: crucial gene and cell machinery discoveries. Lancet Neurol. 2016 Jan;15(1):12-3.

 

Pagani M, Öberg J, De Carli F, Calvo A, Moglia C, Canosa A, Nobili F, Morbelli S, Fania P, Cistaro A, Chiò A. Metabolic spatial connectivity in amyotrophic lateral sclerosis as revealed by independent component analysis. Hum Brain Mapp. 2016 Mar;37(3):942-53.

 

Chiò A, Mora G, Sabatelli M, Caponnetto C, Lunetta C, Traynor BJ, Johnson JO,  Nalls MA, Calvo A, Moglia C, Borghero G, Trojsi F, La Bella V, Volanti P, Simone I, Salvi F, Logullo FO, Riva N, Carrera P, Giannini F, Mandrioli J, Tanel R, Capasso M, Tremolizzo L, Battistini S, Murru MR, Origone P, Zollino M, Penco S; ITALSGEN consortium; SARDINIALS consortium, Mazzini L, D'Alfonso S, Restagno G, Brunetti M, Barberis M, Conforti FL. ATNX2 is not a regulatory gene in Italian amyotrophic lateral sclerosis patients with C9ORF72 GGGGCC expansion. Neurobiol Aging. 2016 Mar;39:218.e5-8. doi: 10.1016/j.neurobiolaging.2015.11.027.

 

Agosta F, Ferraro PM, Riva N, Spinelli EG, Chiò A, Canu E, Valsasina P, Lunetta C, Iannaccone S, Copetti M, Prudente E, Comi G, Falini A, Filippi M. Structural brain correlates of cognitive and behavioral impairment in MND. Hum Brain Mapp. 2016 Apr;37(4):1614-26. doi: 10.1002/hbm.23124.

 

Müller HP, Turner MR, Grosskreutz J, Abrahams S, Bede P, Govind V, Prudlo J, Ludolph AC, Filippi M, Kassubek J; Neuroimaging Society in ALS (NiSALS) DTI Study Group; Neuroimaging Society in ALS NiSALS DTI Study Group (including Chiò A). A large-scale multicentre cerebral diffusion tensor imaging study in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2016 Jun;87(6):570-9. doi: 10.1136/jnnp-2015-311952.

 

Chiò A, Brunetti M, Barberis M, Iazzolino B, Montuschi A, Ilardi A, Cammarosano S, Canosa A, Moglia C, Calvo. The Role of APOE in the Occurrence of Frontotemporal Dementia in Amyotrophic Lateral Sclerosis. JAMA Neurol. 2016 Apr 1;73(4):425-30. doi: 10.1001/jamaneurol.2015.4773.

 

Chiò A, Defazio G. A new scale for prognostication in Parkinson disease: Of animals and men. Neurology. 2016 Mar 15;86(11):982-3. doi: 10.1212/WNL.0000000000002435.

 

Marrali G, Salamone P, Casale F, Fuda G, Cugnasco P, Caorsi C, Amoroso A, Calvo A, Lopiano L, Cocito D, Chiò A. NADPH oxidase 2 (NOX2) enzyme activation in patients with chronic inflammatory demyelinating polyneuropathy. Eur J Neurol. 2016 May;23(5):958-63. doi: 10.1111/ene.12971.

 

De Marco G, Lomartire A, Calvo A, Risso A, De Luca E, Mostert M, Mandrioli J, Caponnetto C, Borghero G, Manera U, Canosa A, Moglia C, Restagno G, Fini N, Tarella C, Giordana MT, Rinaudo MT, Chiò A. Monocytes of patients with Amyotrophic Lateral Sclerosis linked to gene mutations display altered TDP-43 subcellular distribution. Neuropathol Appl Neurobiol. 2016 May 14. doi: 10.1111/nan.12328. [Epub ahead of print] PubMed PMID: 27178390.

 

Borghero G, Pugliatti M, Marrosu F, Marrosu MG, Murru MR, Floris G, Cannas A, Occhineri P, Cau TB, Loi D, Ticca A, Traccis S, Manera U, Canosa A, Moglia C, Calvo A, Barberis M, Brunetti M, Gibbs JR, Renton AE, Errichiello E, Zoledziewska M, Mulas A, Qian Y, Din J, Pliner HA, Traynor BJ, Chiò A; ITALSGEN and SARDINALS Consortia. TBK1 is associated with ALS and ALS-FTD in Sardinian patients. Neurobiol Aging. 2016 Jul;43:180.e1-5. doi: 10.1016/j.neurobiolaging.2016.03.028.

 

Chiò A. The quest for exogenous risk factors in ALS: Is there a place for physical activity? Amyotroph Lateral Scler Frontotemporal Degener. 2016 Jul-Aug;17(5-6):311-2.

 

Janssens AI, Ruytings M, Al-Chalabi A, Chio A, Hardiman O, Mcdermott CJ, Meyer T, Mora G, Van Damme P, Van Den Berg LH, Vanhaecht K, Winkler AS, Sermeus W; ALS-CARE Consortium. A mapping review of international guidance on the management and care of amyotrophic lateral sclerosis (ALS). Amyotroph Lateral Scler Frontotemporal Degener. 2016 Jul-Aug;17(5-6):325-36. doi: 10.3109/21678421.2016.1167911.

 

Fogh I, Lin K, Tiloca C, Rooney J, Gellera C, Diekstra FP, Ratti A, Shatunov A, van Es MA, Proitsi P, Jones A, Sproviero W, Chiò A, McLaughlin RL, Sorarù G, Corrado L, Stahl D, Del Bo R, Cereda C, Castellotti B, Glass JD, Newhouse S, Dobson R, Smith BN, Topp S, van Rheenen W, Meininger V, Melki J, Morrison KE, Shaw PJ, Leigh PN, Andersen PM, Comi GP, Ticozzi N, Mazzini L, D'Alfonso S, Traynor BJ, Van Damme P, Robberecht W, Brown RH, Landers JE, Hardiman O, Lewis CM, van den Berg LH, Shaw CE, Veldink JH, Silani V, Al-Chalabi A, Powell J. Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis. JAMA Neurol. 2016 Jul 1;73(7):812-20.  doi: 10.1001/jamaneurol.2016.1114.

 

Fraidakis MJ, Brunetti M, Blackstone C, Filippi M, Chiò A. Novel Compound Heterozygous Spatacsin Mutations in a Greek Kindred with Hereditary Spastic Paraplegia SPG11 and Dementia. Neurodegener Dis. 2016 Jun 18;16(5-6):373-381. doi: 10.1159/000444715.

 

van Rheenen W, Shatunov A, Dekker AM, McLaughlin RL, Diekstra FP, Pulit SL, van der Spek RA, Võsa U, de Jong S, Robinson MR, Yang J, Fogh I, van Doormaal PT, Tazelaar GH, Koppers M, Blokhuis AM, Sproviero W, Jones AR, Kenna KP, van Eijk KR, Harschnitz O, Schellevis RD, Brands WJ, Medic J, Menelaou A, Vajda A, Ticozzi N, Lin K, Rogelj B, Vrabec K, Ravnik-Glavač M, Koritnik B, Zidar J, Leonardis L,  Grošelj LD, Millecamps S, Salachas F, Meininger V, de Carvalho M, Pinto S, Mora JS, Rojas-García R, Polak M, Chandran S, Colville S, Swingler R, Morrison KE, Shaw PJ, Hardy J, Orrell RW, Pittman A, Sidle K, Fratta P, Malaspina A, Topp S, Petri S, Abdulla S, Drepper C, Sendtner M, Meyer T, Ophoff RA, Staats KA, Wiedau-Pazos M, Lomen-Hoerth C, Van Deerlin VM, Trojanowski JQ, Elman L, McCluskey L, Basak AN, Tunca C, Hamzeiy H, Parman Y, Meitinger T, Lichtner P, Radivojkov-Blagojevic M, Andres CR, Maurel C, Bensimon G, Landwehrmeyer B, Brice  A, Payan CA, Saker-Delye S, Dürr A, Wood NW, Tittmann L, Lieb W, Franke A, Rietschel M, Cichon S, Nöthen MM, Amouyel P, Tzourio C, Dartigues JF, Uitterlinden AG, Rivadeneira F, Estrada K, Hofman A, Curtis C, Blauw HM, van der  Kooi AJ, de Visser M, Goris A, Weber M, Shaw CE, Smith BN, Pansarasa O, Cereda C, Del Bo R, Comi GP, D'Alfonso S, Bertolin C, Sorarù G, Mazzini L, Pensato V, Gellera C, Tiloca C, Ratti A, Calvo A, Moglia C, Brunetti M, Arcuti S, Capozzo R, Zecca C, Lunetta C, Penco S, Riva N, Padovani A, Filosto M, Muller B, Stuit RJ; PARALS Registry; SLALOM Group; SLAP Registry; FALS Sequencing Consortium; SLAGEN  Consortium; NNIPPS Study Group, Blair I, Zhang K, McCann EP, Fifita JA, Nicholson GA, Rowe DB, Pamphlett R, Kiernan MC, Grosskreutz J, Witte OW, Ringer T, Prell T, Stubendorff B, Kurth I, Hübner CA, Leigh PN, Casale F, Chio A, Beghi E, Pupillo E, Tortelli R, Logroscino G, Powell J, Ludolph AC, Weishaupt JH, Robberecht W, Van Damme P, Franke L, Pers TH, Brown RH, Glass JD, Landers JE, Hardiman O, Andersen PM, Corcia P, Vourc'h P, Silani V, Wray NR, Visscher PM, de Bakker PI, van Es MA, Pasterkamp RJ, Lewis CM, Breen G, Al-Chalabi A, van den Berg LH, Veldink JH. Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. Nat Genet. 2016 Sep;48(9):1043-8. doi: 10.1038/ng.3622.

 

Kenna KP, van Doormaal PT, Dekker AM, Ticozzi N, Kenna BJ, Diekstra FP, van Rheenen W, van Eijk KR, Jones AR, Keagle P, Shatunov A, Sproviero W, Smith BN, van Es MA, Topp SD, Kenna A, Miller JW, Fallini C, Tiloca C, McLaughlin RL, Vance C, Troakes C, Colombrita C, Mora G, Calvo A, Verde F, Al-Sarraj S, King A, Calini D, de Belleroche J, Baas F, van der Kooi AJ, de Visser M, Ten Asbroek AL, Sapp PC, McKenna-Yasek D, Polak M, Asress S, Muñoz-Blanco JL, Strom TM, Meitinger T, Morrison KE; SLAGEN Consortium, Lauria G, Williams KL, Leigh PN, Nicholson GA, Blair IP, Leblond CS, Dion PA, Rouleau GA, Pall H, Shaw PJ, Turner MR, Talbot K,  Taroni F, Boylan KB, Van Blitterswijk M, Rademakers R, Esteban-Pérez J, García-Redondo A, Van Damme P, Robberecht W, Chio A, Gellera C, Drepper C, Sendtner M, Ratti A, Glass JD, Mora JS, Basak NA, Hardiman O, Ludolph AC,Andersen PM, Weishaupt JH, Brown RH Jr, Al-Chalabi A, Silani V, Shaw CE, van den Berg LH, Veldink JH, Landers JE. NEK1 variants confer susceptibility to amyotrophic lateral sclerosis. Nat Genet. 2016 Sep;48(9):1037-42. doi: 10.1038/ng.3626.

 

Marini C, Cistaro A, Campi C, Calvo A, Caponnetto C, Nobili FM, Fania P, Beltrametti MC, Moglia C, Novi G, Buschiazzo A, Perasso A, Canosa A, Scialò C, Pomposelli E, Massone AM, Bagnara MC, Cammarosano S, Bruzzi P, Morbelli S, Sambuceti G, Mancardi G, Piana M, Chiò A. A PET/CT approach to spinal cord metabolism in amyotrophic lateral sclerosis. Eur J Nucl Med Mol Imaging 2016 Oct;43(11):2061-71.

 

Capponi S, Geuens T, Geroldi A, Origone P, Verdiani S, Cichero E, Adriaenssens E, De Winter V, Bandettini di Poggio M, Barberis M, Chiò A, Fossa P, Mandich P, Bellone E, Timmerman V. Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: the role of HSPB1. Hum Mutat. 2016 Nov;37(11):1202-1208..

 

Arthur KC, Calvo A, Price TR, Geiger JT, Chiò A, Traynor BJ. Projected increase in amyotrophic lateral sclerosis from 2015 to 2040. Nat Commun. 2016 Aug 11;7:12408. doi: 10.1038/ncomms12408.

 

D'Ovidio F, d'Errico A, Farina E, Calvo A, Costa G, Chiò A. Amyotrophic Lateral Sclerosis Incidence and Previous Prescriptions of Drugs for the Nervous System. Neuroepidemiology. 2016 Aug 26;47(1):59-66. doi: 10.1159/000448618.

 

Bartolo M, Chiò A, Ferrari S, Tassorelli C, Tamburin S, Avenali M, Azicnuda E, Calvo A, Caraceni AT, Defazio G, DE Icco R, Formisano R, Franzoni S, Greco E, Jedrychowska I, Magrinelli F, Manera U, Marchioni E, Mariotto S, Monaco S, Pace A, Saviola D, Springhetti I, Tinazzi M, DE Tanti A; Italian Consensus Conference on Pain in Neurorehabilitation (ICCPN). Assessing and treating pain in movement disorders, amyotrophic lateral sclerosis, severe acquired brain injury, disorders of consciousness, dementia, oncology and neuroinfectivology. Evidence and recommendations from the Italian Consensus Conference on Pain in Neurorehabilitation. Eur J Phys Rehabil Med. 2016 Aug 31. [Epub ahead of print] PubMed PMID: 27579582.

 

Canale A, Albera R, Lacilla M, Canosa A, Albera A, Sacco F, Chiò A, Calvo A. Acoustic reflex patterns in amyotrophic lateral sclerosis. Eur Arch Otorhinolaryngol. 2016 Aug 30. [Epub ahead of print] PubMed PMID: 27577043.

 

Bandmann O, Chiò A. Genetics of multiple system atrophy: Back to square one? Neurology. 2016 2016 Oct 11;87(15):1530-1531. PubMed PMID: 27629090.

 

Calvo A, Canosa A, Bertuzzo D, Cugnasco P, Solero L, Clerico M, De Mercanti S, Bersano E, Cammarosano S, Ilardi A, Manera U, Moglia C, Marinou K, Bottacchi E, Pisano F, Mora G, Mazzini L, Chiò A. Influence of cigarette smoking on ALS outcome: a population-based study. J Neurol Neurosurg Psychiatry. 2016 Nov; 87(11):1229-1233. doi: 10.1136/jnnp-2016-313793.

 

Rooney J, Fogh I, Westeneng HJ, Vajda A, McLaughlin R, Heverin M, Jones A, van Eijk R, Calvo A, Mazzini L, Shaw C, Morrison K, Shaw PJ, Robberecht W, Van Damme P, Al-Chalabi A, van den Berg L, Chiò A, Veldink J, Hardiman O. C9orf72 expansion differentially affects males with spinal onset amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2017 Apr;88(4):281. doi: 10.1136/jnnp-2016-314093.

 

Al-Chalabi A, Hardiman O, Kiernan MC, Chiò A, Rix-Brooks B, van den Berg LH. Amyotrophic lateral sclerosis: moving towards a new classification system. Lancet Neurol. 2016 Oct;15(11):1182-94. doi: 10.1016/S1474-4422(16)30199-5.

 

Atassi N, Beghi E, Blanquer M, Boulis NM, Cantello R, Caponnetto C, Chiò A, Dunnett SB, Feldman EL, Vescovi A, Mazzini L; attendees of the International Workshop on Progress in Stem Cells Research for ALS/MND. Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials? Cytotherapy 2016 Dec;18(12):1471-1475. doi: 10.1016/j.jcyt.2016.08.005.

 

2015

 

Floris G, Borghero G, Cannas A, Di Stefano F, Ruiu E, Murru MR, Corongiu D, Cuccu S, Tranquilli S, Sardu C, Marrosu MG, Chiò A, Marrosu F. Constructional apraxia in frontotemporal dementia associated with the C9orf72 mutation: Broadening the clinical and neuropsychological phenotype. Amyotroph Lateral Scler Frontotemporal Degener. 2015 Mar;16(1-2):8-15

 

Canosa A, Calvo A, Moglia C, Barberis M, Brunetti M, Cammarosano S, Manera U, Ilardi A, Restagno G, Chiò A. A novel p.E121G heterozygous missense mutation of SOD1 in an apparently sporadic ALS case with a 14-year course. Amyotroph Lateral Scler Frontotemporal Degener 2015 Mar;16(1-2):127-8

 

Canosa A, Calvo A, Barberis M, Brunetti M, Restagno G, Cammarosano S, Ilardi A, Vigliani MC, Chiò A, Moglia C. Amyotrophic lateral sclerosis onset after prolonged treatment with a VEGF receptors inhibitor. Amyotroph Lateral Scler Frontotemporal Degener. 2014 Oct 22:1-2. [Epub ahead of print] PubMed PMID: 25336094.

 

Chiò A, Pagani M, Agosta F, Calvo A, Cistaro A, Filippi M. Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes. Lancet Neurol. 2014 Dec;13(12):1228-1240.

 

Floris G, Borghero G, Cannas A, Di Stefano F, Murru MR, Corongiu D, Cuccu S, Tranquilli S, Cherchi MV, Serra A, Loi G, Marrosu MG, Chiò A, Marrosu F. Clinical phenotypes and radiological findings in frontotemporal dementia related to TARDBP mutations. J Neurol. 2014 Nov 20.

 

Chiò A, Calvo A, Moglia C, Canosa A, Brunetti M, Barberis M, Restagno G, Conte A, Bisogni G, Marangi G, Moncada A, Lattante S, Zollino M, Sabatelli M, Bagarotti A, Corrado L, Mora G, Bersano E, Mazzini L, D'Alfonso S; For PARALS. ATXN2 polyQ intermediate repeats are a modifier of ALS survival. Neurology. 2015; 20:84(3):251-8

 

Chiò A, Traynor BJ. Motor neuron disease in 2014: Biomarkers for ALS - in search of the Promised Land. Nat Rev Neurol. 2014 Dec 23. doi: 10.1038/nrneurol.2014.250.

 

Lauria G, Dalla Bella E, Antonini G, Borghero G, Capasso M, Caponnetto C, Chiò A, Corbo M, Eleopra R, Fazio R, Filosto M, Giannini F, Granieri E, La Bella V, Logroscino G, Mandrioli J, Mazzini L, Monsurrò MR, Mora G, Pietrini V, Quatrale R, Rizzi R, Salvi F, Siciliano G, Sorarù G, Volanti P, Tramacere I, Filippini G; on behalf of the EPOS Trial Study Group. Erythropoietin in amyotrophic lateral sclerosis: a multicentre, randomised, double blind, placebo controlled, phase III study. J Neurol Neurosurg Psychiatry. 2015 Jan 16. pii: jnnp-2014-308996. doi: 10.1136/jnnp-2014-308996.

 

Chiò A, Mora G, Sabatelli M, Caponnetto C, Traynor BJ, Johnson JO, Nalls MA, Calvo A, Moglia C, Borghero G, Monsurrò MR, La Bella V, Volanti P, Simone I, Salvi F, Logullo FO, Nilo R, Battistini S, Mandrioli J, Tanel R, Murru MR, Mandich P, Zollino M, Conforti FL; ITALSGEN Consortium, Brunetti M, Barberis M, Restagno G, Penco S, Lunetta C. CHCHD10 mutations in an Italian cohort of familial and sporadic amyotrophic lateral sclerosis patients. Neurobiol Aging. 2015 Jan 28. pii: S0197-4580(15)00050-0. doi: 10.1016/j.neurobiolaging.2015.01.017. [Epub ahead of print]

 

Renton AE, Pliner HA, Provenzano C, Evoli A, Ricciardi R, Nalls MA, Marangi G, Abramzon Y, Arepalli S, Chong S, Hernandez DG, Johnson JO, Bartoccioni E, Scuderi F, Maestri M, Gibbs JR, Errichiello E, Chiò A, Restagno G, Sabatelli M, Macek M, Scholz SW, Corse A, Chaudhry V, Benatar M, Barohn RJ, McVey A, Pasnoor M, Dimachkie MM, Rowin J, Kissel J, Freimer M, Kaminski HJ, Sanders DB, Lipscomb B, Massey JM, Chopra M, Howard JF Jr, Koopman WJ, Nicolle MW, Pascuzzi RM, Pestronk A, Wulf C, Florence J, Blackmore D, Soloway A, Siddiqi Z, Muppidi S, Wolfe G, Richman D, Mezei MM, Jiwa T, Oger J, Drachman DB, Traynor BJ. A Genome-wide Association Study of Myasthenia Gravis. JAMA Neurol. 2015 Feb 2. doi: 10.1001/jamaneurol.2014.4103.

 

Agosta F, Galantucci S, Magnani G, Marcone A, Martinelli D, Antonietta Volontè M, Riva N, Iannaccone S, Ferraro PM, Caso F, Chiò A, Comi G, Falini A, Filippi M. MRI signatures of the frontotemporal lobar degeneration continuum. Hum Brain Mapp. 2015 Mar 28. doi: 10.1002/hbm.22794. [Epub ahead of print] PubMed PMID: 25821176.

 

Chiò A, Swash M. Alcohol and amyotrophic lateral sclerosis: a possible neuroprotective effect. Eur J Neurol. 2015 Mar 19. doi: 10.1111/ene.12689. [Epub ahead of print] 

 

Elamin M, Bede P, Montuschi A, Pender N, Chio A, Hardiman O. Predicting prognosis in amyotrophic lateral sclerosis: a simple algorithm. J Neurol. 2015 Jun;262(6):1447-54

 

Tramacere I, Dalla Bella E, Chiò A, Mora G, Filippini G, Lauria G; EPOS Trial Study Group. The MITOS system predicts long-term survival in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2015 Nov; 86(11):1180-5.

 

Lill CM, Rengmark A, Pihlstrøm L, Fogh I, Shatunov A, Sleiman PM, Wang LS, Liu T, Lassen CF, Meissner E, Alexopoulos P, Calvo A, Chio A, Dizdar N, Faltraco F, Forsgren L, Kirchheiner J, Kurz A, Larsen JP, Liebsch M, Linder J, Morrison KE, Nissbrandt H, Otto M, Pahnke J, Partch A, Restagno G, Rujescu D, Schnack C, Shaw  CE, Shaw PJ, Tumani H, Tysnes OB, Valladares O, Silani V, van den Berg LH, van Rheenen W, Veldink JH, Lindenberger U, Steinhagen-Thiessen E; SLAGEN Consortium,  Teipel S, Perneczky R, Hakonarson H, Hampel H, von Arnim CA, Olsen JH, Van Deerlin VM, Al-Chalabi A, Toft M, Ritz B, Bertram L. The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease. Alzheimers Dement. 2015 Apr 29. pii: S1552-5260(15)00122-3. doi: 10.1016/j.jalz.2014.12.009. [Epub ahead of print] PubMed PMID: 25936935.

 

Lenzi J, De Santis R, de Turris V, Morlando M, Laneve P, Calvo A, Caliendo V, Chiò A, Rosa A, Bozzoni I. ALS mutant FUS proteins are recruited into stress granules in induced Pluripotent Stem Cells (iPSCs) derived motoneurons. Dis Model Mech. 2015 Jul 1;8(7):755-66

 

Chiò A, Mora G, Sabatelli M, Caponnetto C, Lunetta C, Traynor BJ, Johnson JO, Nalls MA, Calvo A, Moglia C, Borghero G, Monsurrò MR, La Bella V, Volanti P, Simone I, Salvi F, Logullo FO, Riva N, Giannini F, Mandrioli J, Tanel R, Murru MR, Mandich P, Zollino M, Conforti FL, Penco S; ITALSGEN consortium; SARDINIALS consortium, Brunetti M, Barberis M, Restagno G. HFE p.H63D polymorphism does not influence ALS phenotype and survival. Neurobiol Aging. 2015 Oct;36(10):2906.e7-11.

 

Borghero G, Pugliatti M, Marrosu F, Marrosu MG, Murru MR, Floris G, Cannas A, Parish LD, Cau TB, Loi D, Ticca A, Traccis S, Manera U, Canosa A, Moglia C, Calvo A, Barberis M, Brunetti M, Renton AE, Nalls MA, Traynor BJ, Restagno G, Chiò A; ITALSGEN and SARDINALS consortia. ATXN2 is a modifier of phenotype in ALS patients of Sardinian ancestry. Neurobiol Aging. 2015 Oct;36(10):2906.e1-5.

 

Veronese S, Gallo G, Valle A, Cugno C, Chiò A Specialist palliative care improves the quality of life in advanced neurodegenerative disorders: NE-PAL, a pilot randomised controlled study. BMJ Support Palliat Care. 2015 Jul 16. pii: bmjspcare-2014-000788. doi: 10.1136/bmjspcare-2014-000788.

 

Cannas A, Solla P, Borghero G, Floris GL, Chio A, Mascia MM, Modugno N, Muroni A, Orofino G, Di Stefano F, Calvo A, Moglia C, Restagno G, Meloni M, Farris R, Ciaccio D, Puddu R, Vacca MI, Melis R, Murru MR, Tranquilli S, Corongiu D, Rolesu M, Cuccu S, Marrosu MG, Marrosu F. C9ORF72 intermediate repeat expansion in patients affected by atypical parkinsonian syndromes or Parkinson's disease complicated by psychosis or dementia in a Sardinian population. J Neurol. 2015 Nov;262(11):2498-503.

 

Benedetti MD, Pugliatti M, D'Alessandro R, Beghi E, Chiò A, Logroscino G, Filippini G, Galeotti F, Massari M, Santuccio C, Raschetti R; ITANG Study Group. A Multicentric Prospective Incidence Study of Guillain-Barré Syndrome in Italy. The ITANG Study. Neuroepidemiology. 2015;45(2):90-9.

 

Chiò A, Gianetto C, Dagna S. Professor Camillo Negro's Neuropathological Films. J Hist Neurosci. 2016 Jan-Mar; 25(1):39-50.

 

Barbero P, Busso M, Tinivella M, Artusi CA, De Mercanti S, Cucci A, Veltri A, Avagnina P, Calvo A, Chiò A, Durelli L, Clerico M. Long-term follow-up of ultrasound-guided botulinum toxin-A injections for sialorrhea in neurological dysphagia. J Neurol. 2015 Dec;262(12):2662-2667.

249. Cappellato V, Bosco N, Chiò A, Calvo A. Curable or treatable? The implications of different definitions of illness when treating patients suffering from amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2015;17(1-2):15-20. doi: 10.3109/21678421.2015.1074702.

 

Marin B, Bianchi E, Pupillo E, Lunetta C, Tremolizzo L, Logroscino G, Chiò A, Preux PM, Beghi E. Non-self-sufficiency as a primary outcome measure in ALS trials. Amyotroph Lateral Scler Frontotemporal Degener. 2015;17(1-2):77-84. doi: 10.3109/21678421.2015.1074704.

 

2014

 

Agosta F, Galantucci S, Riva N, Chiò A, Messina S, Iannaccone S, Calvo A, Silani V, Copetti M, Falini A, Comi G, Filippi M. Intrahemispheric and interhemispheric structural network abnormalities in PLS and ALS. Hum Brain Mapp. Hum Brain Mapp. 2014 Apr;35(4):1710-22. doi: 10.1002/hbm.22286.

 

Mok K, Laaksovirta H, Tienari PJ, Peuralinna T, Myllykangas L, Chiò A, Traynor BJ, Nalls MA, Gurunlian N, Shatunov A, Restagno G, Mora G, Nigel Leigh P, Shaw CE, Morrison KE, Shaw PJ, Al-Chalabi A, Hardy J, Orrell RW. Homozygosity analysis in amyotrophic lateral sclerosis. Eur J Hum Genet. 2013 Dec;21(12):1429-35

 

Factor-Litvak P, Al-Chalabi A, Ascherio A, Bradley W, Chío A, Garruto R, Hardiman O, Kamel F, Kasarskis E, McKee A, Nakano I, Nelson LM, Eisen A. Current pathways for epidemiological research in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 2013;14 Suppl 1:33-43.

 

Chio A, Logroscino G, Traynor BJ, Collins J, Simeone JC, Goldstein LA, White LA. Global epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literature. Neuroepidemiology 2013; 41:118-130.

 

Chiò A, Battistini S, Calvo A, Caponnetto C, Conforti FL, Corbo M, Giannini F, Mandrioli J, Mora G, Sabatelli M, the ITALSGEN Consortium, Ajmone C, Mastro E, Pain D, Mandich P, Penco S, Restagno G, Zollino M, Surbone A. Genetic counselling in ALS: facts, uncertainties and clinical suggestions. J Neurol Neurosurg Psychiatry 2014 May;85(5):478-85.

 

Agosta F, Canu E, Inuggi A, Chiò A, Riva N, Silani V, Calvo A, Messina S, Falini A, Comi G, Filippi M. Resting state functional connectivity alterations in primary lateral sclerosis. Neurobiol Aging. 2014 Apr;35(4):916-25. doi: 10.1016/j.neurobiolaging.2013.09.041.

 

Goris A, van Setten J, Diekstra F, Ripke S, Patsopoulos NA, Sawcer SJ; The International Multiple Sclerosis Genetics Consortium, van Es M; The Australia and New Zealand MS Genetics Consortium, Andersen PM, Melki J, Meininger V, Hardiman O, Landers JE, Brown R Jr, Shatunov A, Leigh N, Al-Chalabi A, Shaw CE, Traynor BJ, Chiò A, Restagno G, Mora G, Ophoff RA, Oksenberg JR, Van Damme P, Compston A, Robberecht W, Dubois B, van den Berg LH, De Jager PL, Veldink JH, de Bakker PI. No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis. Hum Mol Genet 2014 Apr 1;23(7):1916-22. doi: 10.1093/hmg/ddt574.

 

Fogh I, Ratti A, Gellera C, Lin K, Tiloca C, Moskvina V, Corrado L, Sorarù G, Cereda C, Corti S, Gentilini D, Calini D, Castellotti B, Mazzini L, Querin G, Gagliardi S, Del Bo R, Conforti FL, Siciliano G, Inghilleri M, Saccà F, Bongioanni P, Penco S, Corbo M, Sorbi S, Filosto M, Ferlini A, Di Blasio AM, Signorini S, Shatunov A, Jones A, Shaw PJ, Morrison KE, Farmer AE, Van Damme P, Robberecht W, Chiò A, Traynor BJ, Sendtner M, Melki J, Meininger V, Hardiman O, Andersen PM, Leigh NP, Glass JD, Overste D, Diekstra FP, Veldink JH, van Es MA, Shaw CE, Weale ME, Lewis CM, Williams J, Brown RH, Landers JE, Ticozzi N, Ceroni M, Pegoraro E, Comi GP, D'Alfonso S, van den Berg LH, Taroni F, Al-Chalabi A, Powell J, Silani V; the SLAGEN Consortium Collaborators. A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis. Hum Mol Genet. 2014 Apr 15;23(8):2220-31.

 

Canu E, Agosta F, Galantucci S, Chiò A, Riva N, Silani V, Falini A, Comi G, Filippi M. Extramotor damage is associated with cognition in primary lateral sclerosis patients. PLoS One. 2013 Dec 5;8(12):e82017.

 

Renton AE, Chiò A, Traynor BJ. State of play in amyotrophic lateral sclerosis genetics. Nat Neurosci. 2014 Jan;17(1):17-23.206. doi: 10.1038/nn.3584

 

Chiò A, Hammond ER, Mora G, Bonito V, Filippini G. Development and evaluation  of a clinical staging system for amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2015 Jan;86(1):38-44.

 

Calvo A, Moglia C, Canosa A, Brunetti M, Barberis M, Traynor BJ, Carrara G, Valentini C, Restagno G, Chiò A. A de novo nonsense mutation of the FUS gene in an apparently familial amyotrophic lateral sclerosis case. Neurobiol Aging. 2014; 35(6):1513.e7-1513.e11.

 

De Marco G, Lomartire A, Mandili G, Lupino E, Buccinnà B, Ramondetti C, MogliaC, Novelli F, Piccinini M, Mostert M, Rinaudo MT, Chiò A, Calvo A. Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases. Biochim Biophys Acta. 2014 1843(4):725-34.

 

Agosta F, Canu E, Inuggi A, Chiò A, Riva N, Silani V, Calvo A, Messina S, Falini A, Comi G, Filippi M. Resting state functional connectivity alterations in primary lateral sclerosis. Neurobiol Aging. 2014 Apr;35(4):916-25.

 

Cistaro A, Pagani M, Montuschi A, Calvo A, Moglia C, Canosa A, Restagno G, Brunetti M, Traynor BJ, Nobili F, Carrara G, Fania P, Lopiano L, Valentini MC, Chiò A. The metabolic signature of C9ORF72-related ALS: FDG PET comparison with nonmutated patients. Eur J Nucl Med Mol Imaging 2014; 41(5):844-52.

 

Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, Pittman A, Orrell RW, Malaspina A, Sidle KC, Fratta P, Harms MB, Baloh RH, Pestronk A, Weihl CC, Rogaeva E, Zinman L, Drory VE, Borghero G, Mora G, Calvo A, Rothstein JD, Drepper C, Sendtner M, Singleton AB, Taylor JP, Cookson MR, Restagno G, Sabatelli M, Bowser R, Chiò A, Traynor BJ. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nat Neurosci 2014 May;17(5):664-6.

 

Pupillo E, Messina P, Giussani G, Logroscino G, Zoccolella S, Chiò A, Calvo A, Corbo M, Lunetta C, Marin B, Mitchell D, Hardiman O, Rooney J, Stevic Z, Bandettini di Poggio M, Filosto M, Cotelli MS, Perini M, Riva N, Tremolizzo L, Vitelli E, Damiani D, Beghi E; the EURALS Consortium. Physical Activity and ALS. A European Population-based, Case-control Study. Ann Neurol. 2014 May;75(5):708-16.

 

Montuschi A, Iazzolino B, Calvo A, Moglia C, Lopiano L, Restagno G, Brunetti M, Ossola I, Lo Presti A, Cammarosano S, Canosa A, Chiò A. Cognitive correlates in amyotrophic lateral sclerosis: a population-based study in Italy. J Neurol Neurosurg Psychiatry. 2015 Feb;86(2):168-173

 

Canosa A, Calvo A, Moglia C, Iazzolino B, Brunetti M, Restagno G, Cistaro A, Fania P, Carrara G, Valentini MC, Tanel R, Chiò A. A familial ALS case carrying a novel p.G147C SOD1 heterozygous missense mutation with non-executive cognitive impairment. J Neurol Neurosurg Psychiatry. 2014 Dec;85(12):1437-9.

 

van Doormaal PT, Ticozzi N, Gellera C, Ratti A, Taroni F, Chiò A, Calvo A, Mora G, Restagno G, Traynor BJ, Birve A, Lemmens R, van Es MA, Saris CG, Blauw HM, van Vught PW, Groen EJ, Corrado L, Mazzini L, Del Bo R, Corti S, Waibel S, Meyer T, Ludolph AC, Goris A, van Damme P, Robberecht W, Shatunov A, Fogh I, Andersen PM, D'Alfonso S, Hardiman O, Cronin S, Rujescu D, Al-Chalabi A, Landers JE, Silani V, van den Berg LH, Veldink JH. Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicentre survival study. Neurobiol Aging. 2014 Oct;35(10):2420.e13-4

 

Veronese S, Valle A, Chiò A, Calvo A, Oliver D. The last months of life of people with amyotrophic lateral sclerosis in mechanical invasive ventilation: a qualitative study. Amyotroph Lateral Scler Frontotemporal Degener.  2014 Dec;15(7-8):499-504.

 

Chiò A, Calvo A, Bovio G, Canosa A, Bertuzzo D, Galmozzi F, Cugnasco P, Clerico M, De Mercanti S, Bersano E, Cammarosano S, Ilardi A, Manera U, Moglia C, Sideri R, Marinou K, Bottacchi E, Pisano F, Cantello R, Mazzini L, Mora G; Piemonte and Valle d'Aosta Register for Amyotrophic Lateral Sclerosis (PARALS). Amyotrophic lateral sclerosis outcome measures and the role of albumin and creatinine: a population-based study. JAMA Neurol. 2014 Sep 1;71(9):1134-42.

 

Keller MF, Ferrucci L, Singleton AB, Tienari PJ, Laaksovirta H, Restagno G, Chiò A, Traynor BJ, Nalls MA. Genome-wide analysis of the heritability of amyotrophic lateral sclerosis. JAMA Neurol. 2014 Sep 1;71(9):1123-34.

 

Ilardi A, Moglia C, Cammarosano S, Canosa A, Bertuzzo D, Manera U, Fuda G, Chiò A, Calvo A. Persistent idiopathic hypoglossal nerve palsy: A motor neuron disease-mimic syndrome? Amyotroph Lateral Scler Frontotemporal Degener. 2014 Jun 12:1-3.

 

Diekstra FP, Van Deerlin VM, van Swieten JC, Al-Chalabi A, Ludolph AC, Weishaupt JH, Hardiman O, Landers JE, Brown RH Jr, van Es MA, Pasterkamp RJ, Koppers M, Andersen PM, Estrada K, Rivadeneira F, Hofman A, Uitterlinden AG, van  Damme P, Melki J, Meininger V, Shatunov A, Shaw CE, Leigh PN, Shaw PJ, Morrison KE, Fogh I, Chiò A, Traynor BJ, Czell D, Weber M, Heutink P, de Bakker PI, Silani V, Robberecht W, van den Berg LH, Veldink JH. C9orf72 and UNC13A are shared risk  loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis. Ann Neurol. 2014 Jul;76(1):120-33.

 

Pagani M, Chiò A, Valentini MC, Oberg J, Nobili F, Calvo A, Moglia C, Bertuzzo D, Morbelli S, De Carli F, Fania P, Cistaro A. Functional pattern of brain FDG-PET in amyotrophic lateral sclerosis. Neurology 2014 83(12):1067-74.

 

Borghero G, Pugliatti M, Marrosu F, Marrosu MG, Murru MR, Floris G, Cannas A, Parish LD, Occhineri P, Cau TB, Loi D, Ticca A, Traccis S, Manera U, Canosa A, Moglia C, Calvo A, Barberis M, Brunetti M, Pliner HA, Renton AE, Nalls MA, Traynor BJ, Restagno G, Chiò A; ITALSGEN and SARDINALS Consortia. Genetic architecture of ALS in Sardinia. Neurobiol Aging. 2014 Dec;35(12):2882.e7-2882.e12.

 

Marrali G, Casale F, Salamone P, Fuda G, Caorsi C, Amoroso A, Brunetti M, Restagno G, Barberis M, Bertuzzo D, Canosa A, Moglia C, Calvo A, Chiò A. NADPH oxidase (NOX2) activity is a modifier of survival in ALS. J Neurol 2014 Nov;261(11):2178-83.

 

Al-Chalabi A, Calvo A, Chio A, Colville S, Ellis CM, Hardiman O, Heverin M, Howard RS, Huisman MH, Keren N, Leigh PN, Mazzini L, Mora G, Orrell RW, Rooney J, Scott KM, Scotton WJ, Seelen M, Shaw CE, Sidle KS, Swingler R, Tsuda M, Veldink JH, Visser AE, van den Berg LH, Pearce N. Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study. Lancet Neurol 2014 Nov; 13(11):1108-13.

 

Johnson JO, Glynn SM, Gibbs JR, Nalls MA, Sabatelli M, Restagno G, Drory VE, Chiò A, Rogaeva E, Traynor BJ. Mutations in the CHCHD10 gene are a common cause of familial amyotrophic lateral sclerosis. Brain 2014 Dec;137(Pt 12):e311

 

2013

 

Ahmeti K, Ajroud-Driss S, Al-Chalabi A, Andersen PM, Armstrong J, Birve A, Blauw H, Brown R, Bruijn L, Chen W, Chio' A, Comeau M, Cronin S, Diekstra F, Soraya Gkazi A, Glass J, Grab J, Groen E, Haines J, Hardiman O, Heller S, Huang J, Hung W-Y, ITALSGEN Consortium, Jaworski J, Jones A, Khan H, Landers J, Langefeld C, Leigh NP, Marion M, McLaughlin R, Meininger V, Melki J, Miller J, Mora G, Pericak-Vance M, Rampersaud E, Robberecht W, Russell L, Salachas F, Saris C, Shatunov A, Shaw C, Siddique N, Siddique T, Smith B, Sufit R, Topp S, Traynor BJ, Vance C, van Damme P, Van den Berg L, van Es M, van Vught P, Veldink J, Yang YZheng JG. Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. Neurobiol Aging 2013; 357.e7-357.e19.

 

Migliaretti G, Berchialla P, Dalmasso P, Cavallo F, Chiò A. Amyotrophic lateral sclerosis in Piedmont (Italy): A Bayesian spatial analysis of the incident cases. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Jan;14(1):58-65.  doi: 10.3109/21678421.2012.733401.

 

Floris G, Borghero G, Cannas A, Stefano FD, Murru MR, Corongiu D, Cuccu S, Tranquilli S, Marrosu MG, Chiò A, Marrosu F. Bipolar affective disorder preceding frontotemporal dementia in a patient with C9ORF72 mutation: is there a genetic link between these two disorders? J Neurol. 2013 Apr;260(4):1155-7

 

Vucic S, Nicholson GA, Chio A, Kiernan MC. Apparent anticipation in SOD1 familial amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Sep;14(5-6):452-6. 10.3109/21678421.2013.764569

 

Turner MR, Hardiman O, Benatar M, Brooks BR, Chio A, de Carvalho M, Ince PG, Lin C, Miller RG, Mitsumoto H, Nicholson G, Ravits J, Shaw PJ, Swash M, Talbot K, Traynor BJ, Van den Berg LH, Veldink JH, Vucic S, Kiernan MC. Controversies and priorities in amyotrophic lateral sclerosis. Lancet Neurol 2013; 12: 310-22

 

Chiò A, Mora G, Restagno G, Brunetti M, Ossola I, Barberis M, Ferrucci L, Canosa A, Manera U, Moglia C, Fuda G, Traynor BJ, Calvo A. UNC13A influences survival in Italian amyotrophic lateral sclerosis patients: a population-based study. Neurobiol Aging 2013; 34: 357.e1-357.e5

 

Beghi E, Pupillo E, Bonito V, Buzzi P, Caponnetto C, Chiò A, Corbo M, Giannini F, Inghilleri M, Bella VL, Logroscino G, Lorusso L, Lunetta C, Mazzini L, Messina P, Mora G, Perini M, Quadrelli ML, Silani V, Simone IL, Tremolizzo L. Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Sep;14(5-6):397-405. doi: 10.3109/21678421.2013.764568

 

Pugliatti M, Parish LD, Cossu P, Leoni S, Ticca A, Saddi MV, Ortu E, Traccis S, Borghero G, Puddu R, Chiò A, Pirina P. Amyotrophic lateral sclerosis in Sardinia, insular Italy, 1995-2009. J Neurol 2013; 260:572-599

 

Chiò A, Mora G. The final chapter of the ALS lithium saga. Lancet Neurol. 2013 Apr;12(4):324-5

 

Galeotti F, Massari M, D'Alessandro R, Beghi E, Chiò A, Logroscino G, Filippini G, Benedetti MD, Pugliatti M, Santuccio C, Raschetti R; The ITANG study group. Risk of Guillain-Barré syndrome after 2010-2011 influenza vaccination. Eur J Epidemiol 2013; 28:433-444

 

Cannas A, Borghero G, Floris GL, Solla P, Chiò A, Traynor BJ, Calvo A, Restagno G, Majounie E, Costantino E, Piras V, Lavra L, Pani C, Orofino G, Di Stefano F, Tacconi P, Mascia MM, Muroni A, Murru MR, Tranquilli S, Corongiu D, Rolesu M, Cuccu S, Marrosu F, Marrosu MG. The p.A382T TARDBP gene mutation in Sardinian patients affected by Parkinson's disease and other degenerative parkinsonisms. Neurogenetics. 2013; 14(2):161-6

 

Franchignoni F, Mora G, Giordano A, Volanti P, Chiò A. Evidence of multidimensionality in the ALSFRS-R Scale: a critical appraisal on its measurement properties using Rasch analysis. J Neurol Neurosurg Psychiatry. 2013 Dec;84(12):1340-5.

 

Bartolome F, Wu HC, Burchell VS, Preza E, Wray S, Mahoney CJ, Fox NC, Calvo A, Canosa A, Moglia C, Mandrioli J, Chiò A, Orrell RW, Houlden H, Hardy J, Abramov AY, Plun-Favreau H. Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels. Neuron. 2013 10;78(1):57-64. pii: S0896-6273(13)00186-4. doi: 10.1016/j.neuron.2013.02.028.

 

2012

 

The EFNS Task Force on Diagnosis and Management of Amyotrophic Lateral Sclerosis:, Andersen PM, Abrahams S, Borasio GD, de Carvalho M, Chio A, Van Damme P, Hardiman O, Kollewe K, Morrison KE, Petri S, Pradat PF, Silani V, Tomik B, Wasner M, Weber M. EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) - revised report of an EFNS task force. Eur J Neurol 2012; 19:360-375.

doi: 10.1111/j.1468-1331.2011.03501.x.

 

Majounie E, Traynor BJ, Chiò A, Restagno G, Mandrioli J, Benatar M, Taylor JP, Singleton AB. Mutational analysis of the VCP gene in Parkinson's disease. Neurobiol Aging 2012 Jan; 33(1):209.e1-2

Mok K, Traynor BJ, Schymick J, Tienari PJ, Laaksovirta H, Peuralinna T, Myllykangas L, Chiò A, Shatunov A, Boeve BF, Boxer AL, Dejesus-Hernandez M, Mackenzie IR, Waite A, Williams N, Morris HR, Simón-Sánchez J, van Swieten JC, Heutink P, Restagno G, Mora G, Morrison KE, Shaw PJ, Rollinson PS, Al-Chalabi A,  Rademakers R, Pickering-Brown S, Orrell RW, Nalls MA, Hardy J. The chromosome 9 ALS and FTD locus is probably derived from a single founder. Neurobiol Aging. 2012 Jan; 33(1):209.e3-8

 

 Chiò A, Calvo A, Moglia C, Gamna F, Mattei A, Mazzini L, Mora G; and the PARALS. Non-invasive ventilation in amyotrophic lateral sclerosis: a 10 year population based study. J Neurol Neurosurg Psychiatry. 2012; 83:377-381. doi:10.1136/jnnp-2011-300472

 

Cistaro A, Valentini MC, Chiò A, Nobili F, Calvo A, Moglia C, Montuschi A, Morbelli S, Salmaso D, Fania P, Carrara G, Pagani M. Brain hypermetabolism in amyotrophic lateral sclerosis: a FDG PET study in ALS of spinal and bulbar onset. Eur J Nucl Med Mol Imaging. 2012 Feb;39(2):251-259.

 

Floris G, Borghero G, Chiò A, Secchi L, Cannas A, Sardu C, Calvo A, Moglia C, Marrosu MG. Cognitive screening in patients with amyotrophic lateral sclerosis in early stages. Amyotroph Lateral Scler. 2012 Jan;13(1):95-101

 

Carrara G, Carapelli C, Venturi F, Ferraris MM, Lequio L, Chiò A, Calvo A, Sirgiovanni S, Cistaro A, Valentini MC. A Distinct MR Imaging Phenotype in Amyotrophic Lateral Sclerosis: Correlation between T1 Magnetization Transfer Contrast Hyperintensity along the Corticospinal Tract and Diffusion Tensor Imaging Analysis. Am J Neuroradiol 2012; 33:733-739

 

Chiò A, Canosa A, Gallo S, Moglia C, Ilardi A, Cammarosano S, Papurello D, Calvo A. Pain in amyotrophic lateral sclerosis: a population-based controlled study. Eur J Neurol. 2012; 19:551-555.

 

Floris G, Borghero G, Cannas A, Di Stefano F, Costantino E, Murru MR, Brunetti M, Restagno G, Traynor BJ, Marrosu MG, Chiò A, Marrosu F. Frontotemporal dementia with psychosis, parkinsonism, visuo-spatial dysfunction,  upper motor  neuron involvement associated to expansion of C9ORF72: a peculiar phenotype? J Neurol. 2012 Feb 10. DOI: 10.1007/s00415-012-6444-3.

 

Chiò A, Borghero G, Restagno G, Mora G, Drepper C, Traynor BJ, Sendtner M, Brunetti M, Ossola I, Calvo A, Pugliatti M, Sotgiu MA, Murru MR, Marrosu MG, Marrosu F, Marinou K, Mandrioli J, Sola P, Caponnetto C, Mancardi G, Mandich P, La Bella V, Spataro R, Conte A, Monsurrò MR, Tedeschi G, Pisano F, Bartolomei I, Salvi F, Lauria Pinter G, Simone I, Logroscino G, Gambardella A, Quattrone A, Lunetta C, Volanti P, Zollino M, Penco S, Battistini S; the ITALSGEN consortium,  Renton AE, Majounie E, Abramzon Y, Conforti FL, Giannini F, Corbo M, Sabatelli M. Clinical characteristics of patients with familial amyotrophic lateral sclerosis carrying the pathogenic GGGGCC hexanucleotide repeat expansion of C9ORF72. Brain 2012 Mar;135(Pt 3):784-793.

 

Chiò A, Mora G. Physical fitness and amyotrophic lateral sclerosis: dangerous liaisons or common genetic pathways? J Neurol Neurosurg Psychiatry. 2012 Apr;83(4):389. (Editorial)

 

Majounie E, Renton AE, Mok K, Dopper EG, Waite A, Rollinson S, Chiò A, RestagnoG, Nicolaou N, Simon-Sanchez J, van Swieten JC, Abramzon Y, Johnson JO, Sendtner M, Pamphlett R, Orrell RW, Mead S, Sidle KC, Houlden H, Rohrer JD, Morrison KE,Pall H, Talbot K, Ansorge O; The Chromosome 9-ALS/FTD Consortium; The French research network on FTLD/FTLD/ALS; The ITALSGEN Consortium, Hernandez DG, Arepalli S, Sabatelli M, Mora G, Corbo M, Giannini F, Calvo A, Englund E,Borghero G, Floris GL, Remes AM, Laaksovirta H, McCluskey L, Trojanowski JQ, Van Deerlin VM, Schellenberg GD, Nalls MA, Drory VE, Lu CS, Yeh TH, Ishiura H,Takahashi Y, Tsuji S, Le Ber I, Brice A, Drepper C, Williams N, Kirby J, Shaw P, Hardy J, Tienari PJ, Heutink P, Morris HR, Pickering-Brown S, Traynor BJ. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. Lancet Neurol. 2012; 11:323-330.

 

Sabatelli M, Conforti FL, Zollino M, Mora G, Monsurrò MR, Volanti P, Marinou K, Salvi F, Corbo M, Giannini F, Battistini S, Penco S, Lunetta C, Quattrone A, Gambardella A, Logroscino G, Simone I, Bartolomei I, Pisano F, Tedeschi G, Conte A, Spataro R, La Bella V, Caponnetto C, Mancardi G, Mandich P, Sola P, Mandrioli J, Renton AE, Majounie E, Abramzon Y, Marrosu F, Marrosu MG, Murru MR, Sotgiu MA, Pugliatti M, Rodolico C; ITALSGEN Consortium, Moglia C, Calvo A, Ossola I, Brunetti M, Traynor BJ, Borghero G, Restagno G, Chiò A. C9ORF72 hexanucleotide repeat expansions in the Italian sporadic ALS population. Neurobiol Aging 2012;  33(8):1848.e15-e20  DOI: NBA 10.1016/j.neurobiolaging.2012.02.011

 

Chiò A, Ilardi A, Cammarosano S, Moglia C, Montuschi A, Calvo A. Neurobehavioral dysfunction in ALS has a negative effect on outcome and use of PEG and NIV. Neurology  2012; 78:1085-1089.

 

Chiò A, Restagno G, Brunetti M, Ossola I, Calvo A, Canosa A, Moglia C, Floris G, Tacconi P, Marrosu F, Marrosu MG, Murru MR, Majounie E, Renton AE, Abramzon Y, Pugliatti M, Sotgiu MA, Traynor BJ, Borghero G; the SARDINIALS Consortium. ALS/FTD phenotype in two Sardinian families carrying both C9ORF72 and TARDBP mutations. J Neurol Neurosurg Psychiatry 2012; 83:730-733.

 

Pupillo E, Messina P, Logroscino G, Zoccolella S, Chiò A, Calvo A, Corbo M, Lunetta C, Micheli A, Millul A, Vitelli E, Beghi E; EURALS Consortium. Trauma and amyotrophic lateral sclerosis: a case-control study from a population-based registry. Eur J Neurol 2012; 19:1509-1517

 

Abramzon Y, Johnson JO, Scholz SW, Taylor JP, Brunetti M, Calvo A, Mandrioli J, Benatar M, Mora G, Restagno G, Chiò A, Traynor BJ. Valosin-containing protein (VCP) mutations in sporadic amyotrophic lateral sclerosis. Neurobiol Aging. 2012;33:2231.e1-e6.  

 

Calvo A, Ilardi A, Moglia C, Canosa A, Carrara G, Valentini C, Ossola I, Brunetti M, Restagno G, Chiò A. An ALS case with a novel D90N-SOD1 heterozygous missense mutation. Amyotroph Lateral Scler  2012; 13:393-395.

 

Rubino E, Rainero I, Chiò A, Rogaeva E, Galimberti D, Fenoglio P, Grinberg Y,  Isaia G, Calvo A, Gentile S, Bruni AC, St George-Hyslop PH, Scarpini E, Gallone S, Pinessi L; For the TODEM Study Group. SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Neurology. 2012 Oct 9;79(15):1556-1562. PubMed PMID: 22972638.

 

Sabatelli M, Lattante S, Conte A, Marangi G, Luigetti M, Del Grande A, Chiò A, Corbo M, Giannini F, Mandrioli J, Mora G, Calvo A, Restagno G, Lunetta C, Penco S, Battistini S, Zeppilli P, Bizzarro A, Capoluongo E, Neri G, Rossini PM, Zollino M. Replication of association of CHRNA4 rare variants with sporadic amyotrophic lateral sclerosis: The Italian multicentre study. Amyotroph Lateral Scler. 2012 Oct;13(6):580-4. PubMed PMID: 22873564.

 

Calvo A, Moglia C, Canosa A, Cistaro A, Valentini C, Carrara G, Soldano E, Ilardi A, Bersano E, Bertuzzo D, Brunetti M, Ossola I, Restagno G, Chiò A. Amyotrophic lateral sclerosis/frontotemporal dementia with predominant manifestations of obsessive-compulsive disorder associated to GGGGCC expansion of the c9orf72 gene. J Neurol. 2012; 259:2723-2725

 

Chiò A, Calvo A, Mazzini L, Cantello R, Mora G, Moglia C, Corrado L, D'Alfonso S, Majounie E, Renton A, Pisano F, Ossola I, Brunetti M, Traynor BJ, Restagno G; On behalf of PARALS. Extensive genetics of ALS: A population-based study in Italy. Neurology 2012; 79:1983-1989

 

2011

 

De Marco G, Lupino E, Calvo A, Moglia C, Buccinnà B, Grifoni S, Ramondetti C, Lomartire A, Rinaudo MT, Piccinini M, Giordana MT, Chiò A. Cytoplasmic accumulation of TDP-43 in circulating lymphomonocytes of ALS patients with and without TARDBP mutations. Acta Neuropathol  2011; 121:611-622

 

Chiò A, Mora G, Bella VL, Caponnetto C, Mancardi G, Sabatelli M, Siciliano G, Silani V, Corbo M, Moglia C, Calvo A, Mutani R, Rutella S, Gualandi F, Melazzini M, Scimè R, Petrini M, Bondesan P, Garbelli S, Mantovani S, Bendotti C, Tarella C; and the STEMALS Study Group. Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: Clinical and biological results from a prospective multicenter study.  Muscle Nerve 2011; 43:189-195.

 

 Lai SL, Abramzon Y, Schymick JC, Stephan DA, Dunckley T, Dillman A, Cookson M, Calvo A, Battistini S, Giannini F, Caponnetto C, Mancardi GL, Spataro R, Monsurrò MR, Tedeschi G, Marinou K, Sabatelli M, Conte A, Mandrioli J, Sola P, Salvi F, Bartolomei I, Lombardo F; the ITALSGEN Consortium, Mora G, Restagno G, Chiò A, Traynor BJ. FUS mutations in sporadic amyotrophic lateral sclerosis. Neurobiol Aging  2011; 32: 550.e1-550.e4

 

 Chiò A, Calvo A, Moglia C, Ossola I, Brunetti M, Sbaiz L, Lai SL, Abramzon Y, Traynor BJ, Restagno G. A de novo missense mutation of the FUS gene in a "true" sporadic ALS case.  Neurobiol Aging 2011; 32:553.e23-553-e26

 

 Beghi E, Chiò A, Couratier P, Esteban J, Hardiman O, Logroscino G, Millul A, Mitchell D, Preux PM, Pupillo E, Stevic Z, Swingler R, Traynor BJ, Van Den Berg LH, Veldink JH, Zoccolella S. The epidemiology and treatment of ALS: Focus on the heterogeneity of the disease and critical appraisal of therapeutic trials. Amyotroph Lateral Scler 2011;12:1-10

 

Chiò A, Borghero G, Pugliatti M, Ticca A, Calvo A, Moglia C, Mutani R, Brunetti M, Ossola I, Marrosu MG, Murru MR, Floris G, Cannas A, Parish LD, Cossu P, Abramzon Y, Johnson JO, Nalls MA, Arepalli S, Chong S, Hernandez DG, Traynor BJ, Restagno G; and the Italian Amyotrophic Lateral Sclerosis Genetic (ITALSGEN) Consortium. Large Proportion of Amyotrophic Lateral Sclerosis Cases in Sardinia are Due to a Single Founder Mutation of the TARDBP Gene. Arch Neurol 2011; 68:594-598

 

Moglia C, Calvo A, Cammarosano S, Ilardi A, Canosa A, Gallo S, Bersano E, Chiò A. Monomelic amyotrophy is not always benign: A case report. Amyotroph Lateral Scler 2011; 12:307-308.

 

Calvo A, Moglia C, Ilardi A, Cammarosano S, Gallo S, Canosa A, Mastro E, Montuschi A, Chiò A. Religiousness is positively associated with quality of life of ALS caregivers. Amyotroph Lateral Scler 2011; 12:168-171.

 

Chiò A, Calvo A, Moglia C, Mazzini L, Mora G; PARALS study group. Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study. J Neurol Neurosurg Psychiatry 2011; 82:740-746 .

 

Chiò A, Tarella C. Too soon, too much. Muscle & Nerve 2011; 44:149-50

 

Chiò A, Canosa A, Calvo A. Prospective epidemiological registers: a valuable tool for uncovering ALS pathogenesis. J Neurol Neurosurg Psychiatry 2011; 82:1066 (editorial).

 

Borghero G, Floris G, Cannas A, Marrosu MG, Murru MR, Costantino E, Parish LD, Pugliatti M, Ticca A, Traynor BJ, Calvo A, Cammarosano S, Moglia C, Cistaro A, Brunetti M, Restagno G, Chiò A. A patient carrying a homozygous p.A382T TARDBP missense mutation shows a syndrome including ALS, extrapyramidal symptoms, and FTD. Neurobiol Aging 2011; 32: 2327.e1-5

 

Renton AE, Majounie E, Waite A, Simón-Sánchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, Scholz SW, Duckworth J, Ding J, Harmer DW, Hernandez DG, Johnson JO, Mok K, Ryten M, Trabzuni D, Guerreiro RJ, Orrell RW, Neal J, Murray A, Pearson J, Jansen IE, Sondervan D, Seelaar H, Blake D, Young K, Halliwell N, Callister JB, Toulson G, Richardson A, Gerhard A, Snowden J, Mann D, Neary D, Nalls MA, Peuralinna T, Jansson L, Isoviita VM, Kaivorinne AL, Hölttä-Vuori M, Ikonen E, Sulkava R, Benatar M, Wuu J, Chiò A, Restagno G, Borghero G, Sabatelli M; The ITALSGEN Consortium, Heckerman D, Rogaeva E, Zinman  L, Rothstein JD, Sendtner M, Drepper C, Eichler EE, Alkan C, Abdullaev Z, Pack SD, Dutra A, Pak E, Hardy J, Singleton A, Williams NM, Heutink P, Pickering-Brown S, Morris HR, Tienari PJ, Traynor BJ. A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD. Neuron. 2011; 72:257-268

 

Beghi E, Pupillo E, Messina P, Giussani G, Chiò A, Zoccolella S, Moglia C, Corbo M, Logroscino G; for the EURALS Group. Coffee and Amyotrophic Lateral Sclerosis: A Possible Preventive Role. Am J Epidemiol. 2011; 174: 1002-1008

 

 Chiò A, Canosa A, Gallo S, Cammarosano S, Moglia C, Fuda G, Calvo A, Mora G; For the PARALS group. ALS clinical trials: Do enrolled patients accurately represent the ALS population? Neurology 2011; 77:1432-1437

 

Chiò A. Commentary to patient/carer perceptions of disability in motor neurone disease and carer coping. Int J Therapy Rehabil  2011; 18:578.

 

Chiò A, Traynor BJ. Identifying potential risk factors for developing amyotrophic lateral sclerosis. Neurodegenerative Disease Management, 2011; 1:463-471 

 

2010

 

Logroscino G, Traynor BJ, Hardiman O, Chiò A, Mitchell D, Swingler RJ, Millul A, Benn E, Beghi E. Incidence of amyotrophic lateral sclerosis in Europe. J Neurol Neurosurg Psychiatry 2010; 81:385-390.

 

Calvo A, Benech F, Ghiglione P, Balma M, Moglia C, Mutani R, Chiò A. Amyotrophic lateral sclerosis mimic syndrome due to a dorsal spinal cord neurofibroma. Neurol Sci. 2010; 31:111-113.

 

Giordana MT, Grifoni S, Votta B, Magistrello M, Vercellino M, Pellerino A, Navone R, Valentini C, Calvo A, Chiò A. Neuropathology of Olfactory Ensheathing Cell Transplantation into the Brain of Two Amyotrophic Lateral Sclerosis (ALS) Patients. Brain Pathol. 2010; 20:730-737.

 

Tarella C, Rutella S, Gualandi F, Melazzini M, Scimè R, Petrini M, Moglia C, Ulla M, Omedé P, Bella VL, Corbo M, Silani V, Siciliano G, Mora G, Caponnetto C, Sabatelli M, Chiò A. Consistent bone marrow-derived cell mobilization following repeated short courses of granulocyte-colony-stimulating factor in patients with amyotrophic lateral sclerosis: results from a multicenter prospective trial. Cytotherapy 2010: 12:50-59.

 

Ludolph AC, Bendotti C, Blaugrund E, Chio A, Greensmith L, Loeffler JP, Mead R, Niessen HG, Petri S, Pradat PF, Robberecht W, Ruegg M, Schwalenstöcker B, Stiller D, van den Berg L, Vieira F, von Horsten S. Guidelines for preclinical animal research in ALS/MND: A consensus meeting. Amyotroph Lateral Scler 2010;11:38-45.

 

Agosta F, Chiò A, Cosottini M, De Stefano N, Falini A, Mascalchi M, Rocca MA,  Silani V, Tedeschi G, Filippi M. The Present and the Future of Neuroimaging in Amyotrophic Lateral Sclerosis. AJNR Am J Neuroradiol. 2010; 31:1769-1777

 

Calvo A, Moglia C, Balma M, Chiò A. Involvement of Immune Response in the Pathogenesis of Amyotrophic Lateral Sclerosis: A Therapeutic Opportunity? CNS Neurol Disord Drug Targets. 2010; 9(3):325-30.

 

Chiò A, Vignola A, Mastro E, Giudici AD, Iazzolino B, Calvo A, Moglia C, Montuschi A. Neurobehavioral symptoms in ALS are negatively related to caregivers' burden and  quality of life. Eur J Neurol. 2010; 17:1298-1303.

 

Beghi E, Logroscino G, Chiò A, Hardiman O, Millul A, Mitchell D, Swingler R, Traynor BJ. Amyotrophic lateral sclerosis, physical exercise, trauma and sports: results of a population-based pilot case-control study. Amyotroph Lateral Scler 2010;11:289-292.

 

Traynor BJ, Nalls M, Lai SL, Gibbs RJ, Schymick JC, Arepalli S, Hernandez D, van der Brug MP, Johnson JO, Dillman A, Cookson M, Moglia C, Calvo A, Restagno G, Mora G, Chiò A. Kinesin-associated protein 3 (KIFAP3) has no effect on survival in a population-based cohort of ALS patients. Proc Natl Acad Sci U S A. 2010; 107:12335-12338

 

Taes I, Goris A, Lemmens R, van Es MA, van den Berg LH, Chio A, Traynor BJ, Birve A, Andersen P, Slowik A, Tomik B, Brown RH Jr, Shaw CE, Al-Chalabi A, Boonen S, Van Den Bosch L, Dubois B, Van Damme P, Robberecht W. Tau levels do not influence human ALS or motor neuron degeneration in the SOD1G93A mouse. Neurology 2010;74:1687-1693.

 

Chiò A, Calvo A, Ghiglione P, Mazzini L, Mutani R, Mora G; for the PARALS. Tracheostomy in amyotrophic lateral sclerosis: a 10-year population-based study in Italy. J Neurol Neurosurg Psychiatry 2010; 81:1141-1143

 

 Chiò A, Calvo A, Moglia C, Restagno G, Ossola I, Brunetti M, Montuschi A, Cistaro A, Ticca A, Traynor BJ, Schymick JC, Mutani R, Marrosu MG, Murru MR, Borghero G. Amyotrophic lateral sclerosis-frontotemporal lobar dementia in 3 families with p.Ala382Thr TARDBP mutations. Arch Neurol 2010; 67:1002-1009.

 

 Chiò A, Borghero G, Calvo A, Capasso M, Caponnetto C, Corbo M, Giannini F, Logroscino G, Mandrioli J, Marcello N, Mazzini L, Moglia C, Monsurrò MR, Mora G,  Patti F, Perini M, Pietrini V, Pisano F, Pupillo E, Sabatelli M, Salvi F, Silani  V, Simone IL, Sorarù G, Tola MR, Volanti P, Beghi E; On behalf of the LITALS Study Group. Lithium carbonate in amyotrophic lateral sclerosis: Lack of efficacy in a dose-finding trial. Neurology 2010; 75:619-625.

 

Shatunov A, Mok K, Newhouse S, Weale ME, Smith B, Vance C, Johnson L, Veldink JH, van Es MA, van den Berg LH, Robberecht W, Van Damme P, Hardiman O, Farmer AE, Lewis CM, Butler AW, Abel O, Andersen PM, Fogh I, Silani V, Chiò A, Traynor BJ, Melki J, Meininger V, Landers JE, McGuffin P, Glass JD, Pall H, Leigh PN, Hardy J, Brown RH Jr, Powell JF, Orrell RW, Morrison KE, Shaw PJ, Shaw CE, Al-Chalabi A. Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study. Lancet Neurol 2010; 9:986-994.

 

Johnson JO, Mandrioli J, Benatar M, Abramzon Y, Van Deerlin VM, Trojanowski JQ, Gibbs JR, Brunetti M, Gronka S, Wuu J, Ding J, McCluskey L, Martinez-Lage M, Falcone D, Hernandez DG, Arepalli S, Chong S, Schymick JC, Rothstein J, Landi F, Wang YD, Calvo A, Mora G, Sabatelli M, Monsurrò MR, Battistini S, Salvi F, Spataro R, Sola P, Borghero G; ITALSGEN Consortium, Galassi G, Scholz SW, Taylor JP, Restagno G, Chiò A, Traynor BJ. Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron. 2010; 68:857-864

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